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Advances in the Regulation of Receptor Tyrosine Kinase on Autophagy |
DONG Xue-ying1,2,LIANG Kai1,2,YE Ke-ying3,ZHOU Ce-fan1,2,**(),TANG Jing-feng1,2,**() |
1 School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, China 2 HBUT National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan 430068, China 3 Animal, Plant and Food Inspection and Quarantine Office, Chengdu Customs, Sichuan, Chengdu 610041, China |
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Abstract Autophagy is a very conservative biological process of lysosomal degradation in eukaryotic evolution, which plays an important role in maintaining cell homeostasis and eliminating harmful components. Receptor tyrosine kinases (RTKs) are a class of kinase proteins that play an important role in the movement and invasion of normal cells and cancer cells. RTKs protein can not only promote autophagy, but also inhibit autophagy. Studies have shown that RTKs can play a regulatory role in tumors and related diseases through autophagy. For example, epidermal growth factor receptor (EGFR) can inhibit autophagy, thereby promoting tumor growth and proliferation; it can also pass RTK/Ras/ERK signaling pathways to induce autophagy, which in turn participates in related diseases such as cellular immune responses. The regulatory effects of RTKs on autophagy and related research results, which provide a basis for the theoretical basis of target targeted therapy were reviewed.
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Received: 23 December 2020
Published: 01 June 2021
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Corresponding Authors:
Ce-fan ZHOU,Jing-feng TANG
E-mail: cefan@whu.edu.com;tangjingfeng@hbut.edu.com
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