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中国生物工程杂志

China Biotechnology
China Biotechnology
China Biotechnology  2021, Vol. 41 Issue (4): 91-99    DOI: 10.13523/j.cb.2012037
    
Patent Analysis on the Development Trend of Industrial Application of Special Yeast
CHEN Ying(),LI Qian
Pantent Examination Cooperation(Beijing) Center of The Patent Office CNIPA,Beijing 100160,China
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Abstract  

Special yeast, as a kind of biological resource different from traditional yeast, has a wide range of industrial application prospects. By retrieving data from the incoPat database, this article takes the patents of industrial applications of special yeast as the research object. From the perspective of patent analysis, the development trend of technology innovation, technology distribution, main application institutions, research hotspots and application advantages of different kinds of global special yeast industry have been reviewed. Data has shown that the global patent publication amount for special yeast industrial technology presented an increasing trend from 2001 to 2020, and reached a peak in 2019. The patent protection areas concentrated in the US,the P. R. China, South Korea, Japan, Europe and other countries or regions, and the R&D focuses of domestic and foreign applicants differed. Foreign industrial biotechnology companies represented by DSM, Namur DuPont and Novozyme focused on the intellectual property rights of a basic technology of a special yeast. The domestic research institutions represented by Jiangnan University laid more stress on the development of Pichia pastoris technological applications. Finally, the differences in the innovation levels of various kinds of special yeasts from multiple technical branches in recent years have been analyzed, aiming to provide reference for decision-making in scientific research and academic works in the industrial application field of special yeasts in China.

Key words： Special yeast      Industrial application      Patent analysis     
Received: 22 December 2020      Published: 30 April 2021
ZTFLH:  Q819  
Corresponding Authors: Ying CHEN     E-mail: amina_chen@163.com
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Cite this article:

CHEN Ying,LI Qian. Patent Analysis on the Development Trend of Industrial Application of Special Yeast. China Biotechnology, 2021, 41(4): 91-99.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.2012037     OR     https://manu60.magtech.com.cn/biotech/Y2021/V41/I4/91

Fig.1 Annual trend of special yeast global industrial patent application
Fig.2 Global patent application distribution of industrial applications of special yeast
Fig.3 Patent application distribution of different special yeast and Saccharomyces cerevisiae technologies
Fig.4 Global applicant rankings of industrial applications of special yeast
Fig.5 Comparison of global applicant rankings of different industrial applications of special yeast
Fig.6 International Patent Classification amount for industrial applications of special yeast
Fig.7 Patent publication trend of the branch technology of special yeast
Fig.8 Patent applicant rankings of industrial applications of special yeast under C12N15, C12N9 and C12N1
主分类号 特殊酵母相关的技术内容 年平均增长率(%)
C12N15 突变或遗传工程涉及的核酸,载体或其分离、制备或纯化 0.29
C12N9 酶及其组合物,制备、活化、抑制、分离或纯化方法 3.87
C12N1 微生物本身及其组合物,培养基,制备方法 0.94
C12P7 含氧有机化合物,如乙醇、丙酮、羧酸、脂肪的制备 -2.11
C12P21 肽或蛋白质,如抗体、谷胱甘肽的制备 -7.66
C12P19 含有糖残基的化合物,如多糖、核苷酸的制备 26.11
C12P13 含氮有机化合物的制备,如氨基酸的制备 10.46
A61K39 含有抗原或抗体的医药配制品 2.66
A61K36 含有来自酵母菌属或其派生物的未确定结构的药物制剂 26.49
A61K38 含肽的医药配制品,如生长因子、白蛋白 -6.13
A61K8 化妆品或类似的梳妆用配制品 6.61
C07K14 酶及其组合物,制备、活化、抑制、分离或纯化方法 -1.93
C07K16 免疫球蛋白,如单克隆抗体、多克隆抗体 5.31
C12G3 果汁酒或其他含酒精饮料及其制备 39.16
A23L1 食品、食料或非酒精饮料 0.72
Table 1 Main technologies in the field of special yeast and the annual average growth rate of patent publication from 2010 to 2019
主分类号
(大组)		 技术内容 特殊酵母细分技术领域每年的专利增长率(%)
2012年 2013年 2014年 2015年 2016年 2017年 2018年 2019年
C12N15 突变或遗传工程涉及的核酸,载体或其分离、制备或纯化 2.70 -12.20 4.09 -0.52 7.89 3.66 0.24 5.87
C12N9 酶及其组合物,制备、活化、抑制、分离或纯化方法 -1.75 -0.45 12.56 24.70 12.46 -7.39 -6.13 11.11
C12N1 微生物本身及其组合物,培养基,制备方法 -7.33 -9.88 6.36 4.54 5.52 12.15 -0.67 2.35
C12P7 含氧有机化合物的制备 -5.56 -8.24 50.64 -11.91 -5.80 -9.23 -14.12 3.29
C12P21 肽或蛋白质的制备 -4.72 -11.57 -2.80 -24.04 -16.46 9.09 5.56 1.32
C12P19 含有糖残基的化合物的制备 39.58 39.58 39.53 20.00 12.50 28.40 -5.77 8.16
C12P13 含氮有机化合物的制备 16.67 -33.33 100.00 21.43 -14.71 41.38 -26.83 36.67
A61K39 含有抗原或抗体的医药配制品 12.24 -30.91 15.79 -11.36 46.15 -8.77 11.54 12.07
A61K36 含有来自酵母菌属或其派生物的未确定结构的药物制剂 72.73 -21.05 300.00 30.00 -69.23 29.17 19.35 -5.41
A61K38 含肽的医药配制品 3.39 -21.31 27.08 -22.95 31.91 -20.97 4.08 -11.76
A61K8 化妆品或类似的梳妆用配制品 35.71 -15.79 31.25 95.24 -31.71 28.57 -30.56 32.00
C07K14 酶及其组合物,制备、活化、抑制、分离或纯化方法 -13.01 -7.48 -3.03 12.50 20.37 -10.00 -1.71 7.83
C07K16 免疫球蛋白 -2.94 -42.42 105.26 12.82 18.18 -9.62 -4.26 15.56
C12G3 果汁酒或其他含酒精饮料及其制备 -62.50 100.00 -16.67 46.67 -4.55 71.43 -2.78 0.00
A23L1 食品、食料或非酒精饮料 37.93 -20.00 143.75 7.69 -52.38 -5.00 -47.37 -15.00
Table 2 Annual patent growth rate of subdivide technical fields of special yeast
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主管：中国科学院 　主办：中国科学院文献情报中心 　中国生物技术发展中心 　中国生物工程学会