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Interaction between Protein Corona and Nanoparticles |
CHU Yu-qi,LU Fei-fei,LIU Yang,HE Fang,WANG Da-zhuang,CHEN Li-jiang() |
School of Pharmaceutical Sciences, Liaoning University, Shenyang 110036, China |
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Abstract In recent years, although nanoparticles have made great progress in biomedical research, they rarely enter clinical trials. This is mainly due to the lack of understanding of the interaction between nanoparticles and the physiological environment and the limited understanding of the biological characteristics of nanoparticles after they enter the body. In the physiological environment, proteins adsorb on the surface of nanoparticles and form protein corona. The formation of this nanoparticles-protein corona complex seriously affects the biological characteristics of nanoparticles and restricts the clinical application of nanoparticles. Therefore, the interaction between protein corona and nanoparticles should be further studied. At present, the research on nanoparticle-protein corona complex is a relatively new field. This review summarizes the research status of protein corona, and focuses on the impact of the interaction between protein corona and nanoparticles. It also introduces methods to prevent and reduce the formation of protein corona, providing ideas for further research and development of nanoparticles.
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Received: 25 October 2019
Published: 18 May 2020
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Corresponding Authors:
Li-jiang CHEN
E-mail: chlj16@163.com
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