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中国生物工程杂志

China Biotechnology
China Biotechnology
China Biotechnology  2020, Vol. 40 Issue (3): 132-143    DOI: 10.13523/j.cb.1907022
Orginal Article     
Properties and Applications of Stimuli-Responsive DNA Hydrogels
CHENG Ping1,ZHANG Yang-zi2,MA Xuan2,CHEN Xu2,ZHU Bao-qing1,XU Wen-tao2,**()
1 College of Biological Science and Technology, Beijing Forestry University, Beijing 100083,China
2 College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083,China
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Abstract  

As a biosynthetic molecule, DNA hydrogels are equipped with specificity, biodegradability and molecular recognition belonging to DNA molecule and high hydrophilicity belonging to hydrogels. Stimuli-responsive DNA hydrogels are mainly prepared by response behaviors of DNA branch structure formed by complementary pairing of bases of DNA sequences or i-motifs formed by DNA special sequences of many functional nucleic acid, T-A·T or C-G·C + triplexes and G-quadruplexes in environment triggers. Recently, stimuli-responsive DNA hydrogels possess broad applications of biosensors, bioimaging, drug delivery, biomaterials etc. with unique response property in single triggers such as temperature, pH, light, metal ions etc. and multi-triggers such as photothermal, metal ions-organics, temperature-pH. The origins of DNA molecule, classification, formation and characterization of stimuli-responsive DNA Hydrogels are developed. Response behaviors to environments and applications of stimuli-responsive DNA hydrogels are reviewed. The current research hotspots of stimuli-responsive DNA hydrogels are summarized. The development trend of stimuli-responsive DNA hydrogels in the future is predicted.



Key words： DNA hydrogel      Stimulus      Biosensors      Drug delivery      Biomaterials     
Received: 10 July 2019      Published: 18 April 2020
ZTFLH:  Q78  
Corresponding Authors: Wen-tao XU     E-mail: xuwentao@cau.edu.cn
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Ping CHENG
Yang-zi ZHANG
Xuan MA
Xu CHEN
Bao-qing ZHU
Wen-tao XU
Cite this article:

CHENG Ping,ZHANG Yang-zi,MA Xuan,CHEN Xu,ZHU Bao-qing,XU Wen-tao. Properties and Applications of Stimuli-Responsive DNA Hydrogels. China Biotechnology, 2020, 40(3): 132-143.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.1907022     OR     https://manu60.magtech.com.cn/biotech/Y2020/V40/I3/132

Fig.1 Three conformations of i-motif (a) Monomer i-motif (b) Dimer i-motif (c) Tetramer i-motif
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