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Advances in Production of Plant Isoquinoline Alkaloids in Heterologous Microbes |
MA Ya-ting1,LIU Zhen-ning1,LIU Xue1,YU Hong-jian2,ZHAO Guang-rong1,**() |
1 School of Chemical Engineering and Technology, Tianjin University, Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin 300350, China 2 Ubasio Biotech Co. , Ltd. , Tianjin 300450, China |
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Abstract Plant isoquinoline alkaloids (PIAs) include morphine, codeine, galantamine, berberine and other pharmaceutically active products. Currently, most high-value PIAs are extracted from plants, which is limited by low concentration in nature, seasonal production and extraction methods. Microbial biosynjournal provides an alternative way to gain PIAs at low cost, however, the long and complex biosynjournal pathways of PIAs bring it many challenges. With the development of synthetic biology and biotechnology, many progresses are made in the pathway elucidations and enzyme identifications, which make it possible to achieve the biosynjournal of PIAs in heterologous microbes. Recent advances in the PIAs pathway elucidations and metabolic engineering in heterologous microbes are reviewed, and current challenges as well as future perspectives are discussed.
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Received: 23 March 2019
Published: 17 December 2019
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Corresponding Authors:
Guang-rong ZHAO
E-mail: grzhao@tju.edu.cn
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