Research Progress of KLF8 Expression, Modification and Oncogenic Mechanism

doi:10.13523/j.cb.20190811

China Biotechnology

2019, Vol. 39

Issue (8): 80-85 DOI: 10.13523/j.cb.20190811

Research Progress of KLF8 Expression, Modification and Oncogenic Mechanism

LIU Shan-hui^1,^2,^3,^*(

),HE Wei⁴,MA Wen-fei⁴,LI Lan-lan^1,^2,³,LU Jian-zhong^1,^2,³,TAO Yan^1,^2,³,ZHANG Jing^1,^2,³,FU Sheng-jun^1,^2,³

1 Institute of Urology, Lanzhou University Second Hospital, Lanzhou 730030, China
2 Key Laboratory of Urological Disease of Gansu Province, Lanzhou 730030, China
3 Institute of Gansu Nephro-Urological Clinical Center, Lanzhou 730030, China
4 The Second Clinical Medical College of Lanzhou University, Lanzhou 730050,China

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Abstract

KLF8 (Krüppel-like factor 8) is a novel member of the Krüppel-like transcription factor family. KLF8 is widely expressed in different tissues such as skin, adipose, and esophagus, etc. Early studies showed that KLF8 protein was possessed of transcriptional inhibitory activity and played an important role in embryonic development. In recent years, increasing studies indicated that KLF8 was highly expressed ubiquitously in various types of tumor tissues, and acted as a transcriptional activator. KLF8 could promote tumorigenesis process through regulation of cell proliferation, migration, invasion, EMT, and cancer cells stemness. This article will review the research progress of KLF8 in recent years and systematically expound KLF8 expression regulation and its oncogenic mechanism. It may provide a reference for comprehensive understanding and further study of KLF8 in tumorigenesis.

Key words： KLF8 Transcriptional activator EMT Cells stemness

Received: 02 January 2019 Published: 18 September 2019

ZTFLH:

Q78

Corresponding Authors: Shan-hui LIU E-mail: liushh2014@lzu.edu.cn

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	Shan-hui LIU
	Wei HE
	Wen-fei MA
	Lan-lan LI
	Jian-zhong LU
	Yan TAO
	Jing ZHANG
	Sheng-jun FU

Cite this article:

LIU Shan-hui,HE Wei,MA Wen-fei,LI Lan-lan,LU Jian-zhong,TAO Yan,ZHANG Jing,FU Sheng-jun. Research Progress of KLF8 Expression, Modification and Oncogenic Mechanism. China Biotechnology, 2019, 39(8): 80-85.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20190811 OR https://manu60.magtech.com.cn/biotech/Y2019/V39/I8/80

Fig.1 Structural relationships of KLFs

Fig.2 KLF8 promotes tumor angiogenesis by up-regulation of VEGF


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