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Research Progress of Optogenetic Techniques |
Xuan-tong GUO1,Chun-bo ZHANG2,**() |
1 Nanchang Joint Programme, Queen Mary University of London, Nanchang 330031, China 2 School of Pharmacy, Nanchang University, Nanchang 330031, China |
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Abstract Optogenetics is an emerging biological technique that combines optics and genetics to precisely control specific cells within organisms. Since the application of microbial opsins, optogenetics has gained substantial progresses in discovering opsins, optic-control methods and genetic strategies that are based on viruses and recombinases. Optogenetics apply widely in modern neuroscience, playing important roles in the study of neural circuits and behavior, the pathological mechanism of various central nervous system diseases and psychiatric disorders. This review summarizes the development of optogenetic techniques, meanwhile emphasizes the latest advances in the opsin exploration and localized expression, aiming to provide references for research in optogenetics and related fields.
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Received: 01 August 2018
Published: 12 April 2019
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Corresponding Authors:
Chun-bo ZHANG
E-mail: cbzhang@ncu.edu.cn
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