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| Response and Resistance of Acid Stress in Industry Microbiology |
| WEI Lv-Chun1, LI Shuang1,2, XU Qing1 |
1. College of Life Science and Pharmacy, Nanjing University of Technology, Nanjing 211816, China;
2. Jiangsu Provincial Innovation Center for Industrial Biotechnology, Nanjing University of Technology, Nanjing 211816, China |
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Abstract The accumulation of organic acid in the process of microorganism fermentation leads to the decrease of pH in the fermentation system. It further results in acid stress and restricts the biomass and target products accumulation. This paper summarized self-adjusting mechanism and self-healing for the acid stress of microorganism. It aimed at making it easy to understand the acid stress mechanism and the relative physiology transformation law when the microorganism suffers from acid stress, offering ideas to improve the acid tolerance for the microorganism.
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Received: 26 December 2013
Published: 25 March 2014
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[1] 金君华, 张昊, 郭慧媛等.乳酸菌酸胁迫应答机制研究进展.中国乳业, 2011, 119: 32-35. Jin J, Zhang H, Guo H, et al. Acid stress responses in lactic acid bacteria. China Dairy, 2011, 119: 32-35.
[2] Bearson S, Bearson B, Foster J W. Acid stress responses in enterobacteria. FEMS Microbiology Letters, 1997, 147(2): 173-180.
[3] van de Guchte M, Serror P, Chervaux C, et al. Stress responses in lactic acid bacteria. Antonie van Leeuwenhoek, 2002, 82(1-4): 187-216.
[4] Andersson C, Petrova E, Berglund K, et al. Maintaining high anaerobic succinic acid productivity by product removal. Bioprocess and Biosystems Engineering, 2010, 33:711-718.
[5] Roa Engel C A, van Gulik W M, Marang L, et al. Development of a low pH fermentation strategy for fumaric acid production by Rhizopusoryzae. Enzyme and Microbial Technology, 2011, 48: 39-47.
[6] Boyd D A, Cvitkovitch D G, Beleiweis A S, et al. Defects in D-Alanyl-Lipoteichoic Acid Synthesis in Streptococcus mutans Results in Acid Sensitivity. Journal of Bacteriology, 2000, 182: 6055-6065.
[7] Fozo E M, Quivey R G. Shifts in the membrane fatty acid profile of Streptococcus mutansenhancesurvival in acidic environments. Applied and Environmental Microbiology, 2004, 70: 929-936.
[8] Mortensen H D, Gori K, Siegumfeldt H, et al. Intracellular pH homeostasis plays a role in the NaCl tolerance of DebaryomyceshansenⅡstrains. Applied Microbiology and Biotechnology, 2006, 71: 713-719.
[9] Abbott D A, Suir E, Duong G H, et al. Catalase overexpression reduces lactic acid-induced oxidative stress in Saccharomyces cerevisiae. Applied and Environmental Microbiology, 2009, 75(8):2320-2325.
[10] Azcarate-Peril M A, McAuliffe O, Altermann E, et al. Microarray analysis of a two-component regulatory system involved in acid resistance and proteolytic activity in Lactobacillus acidophilus. Applied and Environmental Microbiology, 2005, 71: 5794-5804.
[11] Broadbent J R, Larsen R L, Deibel V, et al. Physiological and transcriptional response of Lactobacillus casei ATCC 334 to acid stress. Journal of Bacteriology, 2010, 192: 2445-2458.
[12] de Angelis M, Bini L, Pallini V, et al. The acid-stress response in Lactobacillus sanfranciscensis CB. Microbiol, 2001, 147: 1863-1873.
[13] Sánchez B, Champomier-Vergès MC, del Carmen Collado M, et al. Low-pH adaptation and the acid tolerance response of Bifidobacteriumlongum biotype longum. Applied and Environmental Microbiology, 2007, 73: 6450-6459.
[14] Wu CD, Zhang J, Chen W, et al. A combined physiological and proteomic approach to reveal lactic-acid-induced alterations in Lactobacillus casei Zhang and its mutant with enhanced lactic acid tolerance. Applied and Environmental Microbiology, 2012, 93:707-722.
[15] Abdullah-Al-Mahin, Sugimoto S, Higashi C, et al. Improvement of multiple-stress tolerance and Lactic acid production in Lactococcuslactis NZ9000 under conditions of thermal stress by heterologous expression of Escherichia coli dnaK. Applied and Environmental Microbiology, 2010, 76(13):4277-4285.
[16] Wu R, Zhang W, Sun T, et al. Proteomic analysis of responses of a new probiotic bacterium Lactobacillus casei Zhang to low acid stress. International Journal of Food Microbiology, 2011, 147: 181-187.
[17] Liu L, Li Y, Shi ZH, et al. Enhancement of pyruvate productivity in Torulopsisglabrata: increase of NAD+ availability. Journal of Biotechnology, 2006, 126(2): 173-185.
[18] Sánchez C, Neves AR, Cavalheiro J, et al. Contribution of citrate metabolism to the growth of Lactococcuslactis CRL264 at low pH. Applied and Environmental Microbiology, 2008, 74(4):1136-1144.
[19] Zhang J, Fu R, Hugenholtz J, et al. Glutathione protects Lactococcus lactis against acid stress. Applied and Environmental Microbiology, 2007, 73: 5268-5275.
[20] Kim J E, Eom H J, Kim Y, et al. Enhancing acid tolerance of Leuconostoc mesenteroides with glutathione. Biotechnology Letters, 2012, 34: 683-687.
[21] Guan N, Liu L, Shi H, et al. Systems-level understanding of how Propionibacterium acidipropionici respond to propionic acid stress at the microenvironment levels: Mechanism and application. Journal of Biotechnology, 2013, 167(1): 56-63
[22] Wu C, Zhang J, Du G, et al. Aspartate protects Lactobacillus casei against acid stress. Applied Microbiology and Biotechnology, 2013, 97: 4083-4093.
[23] 徐桂红, 赵心清, 李宁等.锌离子提高絮凝酵母乙酸胁迫耐受性.化工学报, 2012, 63: 1823-1829. Xu G, Zhao X, Li N, et al. Improvement of acetic acid tolerance of self-flocculating yeast by zinc supplementation. CIESC Journal, 2012, 63: 1823-1829.
[24] Klein-Marcuschamer D, Stephanopoulos G. Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105: 2319-2324.
[25] Wang Y, Li Y, Pei X, et al. Genome-shuffling improved acid tolerance and L-lactic acid volumetric productivity in Lactobacillus rhamnosus. Journal of Biotechnology, 2007, 129:510-515.
[26] RalluF, Gruss A, Ehrlich D, et al. Acid and multistress resistant mutants of Lactococcuslactis: identification of intracellular stress signals. Molecular Microbiology, 2000, 35: 517-528.
[27] Ye L, Zhao H, Li ZH. Improved acid tolerance of Lactobacillus pentosus by error-prone whole genome amplification. Bioresource Technology, 2013, 135: 459-463.
[28] Zhang X, Liu S, Takano T. Overexpression of a mitochondrial ATP synthase small subunit gene (AtMtATP6) confers tolerance to several abiotic stresses in Saccharomyces cerevisiae and Arabidopsis thaliana. Biotechnology Letters, 2008, 30: 1289-1294.
[29] Song P, Chen CH, Tian Q Q, etal.Two-stage oxygen supply strategy for enhanced lipase production by Bacillus subtilis based on metabolic flux analysis. Biochemical Engineering Journal, 2013, 71(15):1-10.
[30] 高敏.利用廉价生物质原料发酵生产富马酸的研究.南京:南京工业大学, 2013. Gao M. Fumaric Acid Production by Inexpensive Renewable Materials by Rhizopus oryzae. Nanjing:Nanjing University of Technology, 2013.
[31] Zhang J, Wu C, Du G, et al. Enhanced acid tolerance in Lactobacillus casei by adaptive evolution and compared stress response during acid stress. Biotechnology and Bioprocess Engineering, 2012, 17(2): 283-289.
[32] Sauer U. Evolutionary engineering of industrially important microbial phenotypes. Advances in Biochemical Engineering/Biotechnology, 2001, 73: 129-169.
[33] 陈坚, 廷里, 周景文等.一种耐受高浓度丙酮酸及低 pH 的酵母菌及选育方法. 中国:201010181344.9, 2011-05-1. Chen J, Ting L, Zhou JW, et al. A well-tolerated high concentations of pyruvate and low pH breeding method in yeast. 201010181344.9, 2011-05-1. |
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