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| The Clinical Research Progress for Oncolytic Adenovirus Targeting Cancer Therapy |
| ZHOU Li, HE Wan-wan, ZHU Zhen-nan, YANG Yuan-qin, ZHAO Hong-fang, MA Bu-yun, WANG Yi-gang |
| Xinyuan Institute of Medicine and Biotechnology, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China |
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Abstract Adenovirus has been discovered and successfully isolated since the 1950s,then biologists conduct extensive researches on oncolytic adenovirus.Compared to other viruses,oncolytic adenovirus could infect tumor cells specifically and accomplish an infection-replication cycle in tumor cells,which can specifically kill and destroy cancer cells,but not damage normal cells or tissues.It has become one of the most promising antineoplastic medicines. However,at the process of clinical gene therapy, adenovirus vectors present the problems that lacking tissues or cells specificity,low genetic transfection efficiency of targeting cells and the lack of certain safety.Therefore,it is rather crucial to improve the targeting ability of recombinant adenovirus for cancer gene therapy.According to relevant studies, a variety of oncolytic adenoviruses as vectors of cancer gene for therapy have entered into related clinical trials involving different kinds of cancers,which shows admirable clinical application. It is mainly to focus on the oncolytic adenovirus types, cancer targeting strategies and clinical studies.
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Received: 17 October 2013
Published: 25 December 2013
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