| [1] Cherry J M, Adler C, Ball C, et al. Saccharomyces genome database provides new regulation data. Nucleic Acids Res, 2014, 42: D717-25. doi: 10.1093/nar/gkt1158.
[2] Mattanovich D, Callewaert N, Rouze P, et al. Open access to sequence: browsing the Pichia pastoris genome. Microb Cell Fact, 2009, 8: 53.
[3] Ahmad M,Hirz M,Pichler H, et al. Protein expression in Pichia pastoris: recent achievements and perspectives for heterologous protein production. Appl Microbiol Biotechnol, 2014, 98(12): 5301-5317.
[4] Potvin G, Ahmad A, Zhang Z. Bioprocess engineering aspects of heterologous protein production in Pichia pastoris: A review. Biochemical Engineering Journal, 2012, 64: 91-105.
[5] Hartner F S,Ruth C,Langenegger D, et al. Promoter library designed for fine-tuned gene expression in Pichia pastoris. Nucleic Acids Res, 2008, 36(12): e76.
[6] 熊向华, 赵洪亮, 薛冲, 等. 毕赤酵母醇氧化酶1启动子突变体的分离与鉴定. 生物技术通讯, 2008, 19(1): 11-13. Xiong X H, Zhao H L, Xue C, et al. Isolation and identification of AOX1 promoter mutant in Pichia pastoris. Letters in Biotechnology, 2008, 19(1): 11-13.
[7] Zhang A L, Luo J X, Zhang T Y, et al. Recent advances on the GAP promoter derived expression system of Pichia pastoris. Mol Biol Rep, 2009, 36(6): 1611-1619.
[8] Wu J M, Lin J C, Chieng L L, et al. Combined used of GAP and AOX1 promoter to enhance the expression of human granulocyte-macrophage colony-stimulating factor in Pichia pastoris. Enzyme and Microbial Technology, 2003, 33(4): 453-459.
[9] 李红亮, 陈勇, 陈海容, 等. 应用双启动子共表达体系提高人胰岛素原在毕赤酵母中的表达量. 中国生物制品学杂志, 2012, 25(4): 422-425. Li H L, Chen Y, Chen H R, et al. Increase of expression level of human proinsulin in Pichia pastoris by double promoter coexpression system. Chin J Biologicals April, 2012, 25(4): 422-425.
[10] Rakestraw J A, Sazinsky S L, Piatesi A, et al. Directed evolution of a secretory leader for the improved expression of heterologous proteins and full-length antibodies in S. cerevisiae. Biotechnol Bioeng, 2009, 103(6): 1192-1201.
[11] Lin-Cereghino G P, Stark C M, Kim D, et al. The effect of α-mating factor secretion signal mutations on recombinant protein expression in Pichia pastoris. Gene, 2013, 519(2): 311-317.
[12] Maeda M, Namikawa K, Kobayashi I, et al. Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system. Brain Res, 2006, 1081(1): 34-43.
[13] Pan R, Zhang J, Shen W L, et al. Sequential deletion of Pichia pastoris genes by a self-excisable cassette. FEMS Yeast Res, 2011, 11(3): 292-298.
[14] 傅静. Cre/Loxp重组系统的修饰及其在树干毕赤酵母中的应用. 无锡:江南大学, 2013. Fu J. The modification of Cre/Loxp recombination system and the application in Scheffersomyces stipitis.Wuxi:Jiangnan University,2013.
[15] Piirainen M A, de Ruijter J C, Koskela E V, et al. Glycoengineering of yeasts from the perspective of glycosylation efficiency. Nature Biotechnology, 2014, 31(6): 532-537.
[16] Hamilton S R, Davidson R C, Sethuraman N, et al. Humanization of yeast to produce complex terminally sialylated glycoproteins. Science, 2006, 313(5792): 1441-1443.
[17] Nett J H, Stadheim A T, Li H, et al. A combinatorial genetic library approach to target heterologous glycosylation enzymes to the endoplasmic reticulum or the Golgi apparatus of Pichia pastoris. Yeast, 2011, 28(3): 237-252.
[18] Gao M J, Shi Z P. Process control and optimization for heterologous protein production by methylotrophic Pichia pastoris. Chinese Journal of Chemical Engineering, 2013, 21(2): 113-226.
[19] Surribas A, Geissler D, Gierse A, et al. State variables monitoring by in-situ multi-wavelength fluorescence spectroscopy in heterologous protein production by Pichia pastoris. J Biotechnol, 2006, 124(2): 412-419.
[20] 侯国力, 高敏杰, 丁健, 等. 基于乙醇在线测量的DO-Stat甘油流加策略稳定重组毕赤酵母生产猪α干扰素的性能. 食品与发酵工业, 2014, 40(1): 1-7. Hou G L, Gao M J, Ding J, et al. Stable porcine interferon-α production by Pichia pastoris with an improved DO-stat glycerol feeding strategy based on ethanol on-line measurement. Food and Fermentation Industries, 2014, 40(1): 1-7.
[21] Celik E, Calik P. Production of recombinant proteins by microbes and higher organisms. Biotechnology Adv, 2009, 27(3): 297-306.
[22] Jungo C, Schenk J, Pasquier M M, et al. A quantitative analysis of the benefits of mixed feeds of sorbitol and methanol for production of recombinant avidin with Pichia pastoris. J Biotechnology, 2007, 131(1): 57-66.
[23] Celik E, Calik P, Oliver S G. Fed-batch methanol feeding strategy for recombinant protein production by Pichia pastoris in the presence of co-substrate sorbitol. Yeast, 2009, 26(9): 473-484.
[24] 汪慧会, 金虎, 高敏杰, 等. 甲醇/山梨醇共混流加诱导改变毕赤酵母生产猪α干扰素过程的代谢产能途径强化发酵性能. 生物工程学报, 2012, 28(2): 164-177. Wang H H, Jin H, Gao M J, et al. Enhanced porcine interferon-α production by Pichia pastoris by methanol/sorbitol co-feeding and energy metabolism shift. Chinese Journal of Biotechnology, 2012, 28(2): 164-177.
[25] N äätsaari L, Mistlberger B, Ruth C, et al. Deletion of the Pichia pastoris KU70 homologue facilitates platform strain generation for gene expression and synthetic biology. PLoS One, 2012, 7(6):e39720.
[26] Wu M, Shen Q, Yang Y, et al. Disruption of YPS1 and PEP4 genes reduces proteolytic degradation of secreted HSA/PTH in Pichia pastoris GS115. J Ind Microbiol Biotechno, 2013, 40(6):589-599.
[27] Damasceno L M, Huang C J, Batt C A. Protein secretion in Pichia pastoris and advances in protein production. Appl Microbiol Biotechnol, 2012, 93(1): 31-39. |
