[1] 王重庆.分子免疫学基础.北京: 北京大学出版社,1997:2226. Wang C Q.The Basis of Molecular Immunology.Beijing:Peking University Press,1997:2226.
[2] 陈鸣,府伟灵.噬菌体抗体库技术—基因工程抗体的重大进展.国外医学临床生物化学与检验学分册,2001,22(3):146148. Chen M,Fu W L.Foreign Medical Sciences:Clinic Biochemistry & Medical Test,2001,22(3):146148.
[3] 侯佩强.噬菌体抗体库技术及应用研究进展.疾病控制杂志,2005,9(2):161163. Hou P Q.Chinese Journal of Disease Control and Prevention,2005,9(2):161163.
[4] 吕勇刚,陶开山,窦科峰,等.噬菌体抗体库技术.医学与哲学,2004,25(10):3940. Lv Y G,Tao K S,Dou K F,et al.Medicine and Philosophy,2004,25(10):3940.
[5] 赵玉梅,房师松,赵树进.噬菌体抗体库技术的发展及未来.卫生研究,2004,33(6):765768. Zhao Y M,Fang S S,Zhao S J.Journal of Hygiene Research,2004,33(6):765768.
[6] 李丽芳,张映.噬菌体展示文库的筛选技术.生物技术通报,2005,4:3638. Li L F,Zhang Y.Biotechnology Bulletin,2005,4:3638.
[7] Huston J S,Margolies M N,Haber E.Antibody binding sites.Advances in Protein Chemistry,1996,49:329450.
[8] Robert de Bruin,Kees Spelt,Joseph Mol,et al.Selection of highaffinity phage antibodies from phage display libraries.Nature Biotechnology,1999,17:397399.
[9] Brichta J,Vesela H,Franek M.Production of scFv recombinant fragments against 2,4dichlorophenoxyacetic acid hapten using naive phage library.Vet.Med.Czech,2003,48,(9): 237–247.
[10] Li Yi,William Cockburn,John B Kilpatrick,et al.High affinity ScFvs from a single rabbit immunized with multiple haptens.Biochemical and Biophysical Research Communications,2000,268,398404.
[11] K.Charlton,W.J.Harris,A.J.Porter.The isolation of supersensitive antihapten antibodies from combinatorial antibody libraries derived from sheep.Biosensors & Bioelectronics,2001 (16):639646.
[12] Moghaddam Amir,Inger Lbersli,Kirsti Gebhardt,et al.Selection and characterisation of recombinant singlechain antibodies to the hapten AflatoxinB1 from naive recombinant antibody libraries.Journal of Immunological Methods,2001,254:169181.
[13] 朱建高,孙去病.噬菌体抗体库的筛选策略.国外医学·生理、病理科学与临床分册,2002,22 (2):119121. Zhu J G,Sun Q B.Foreign Medical Sciences:Pathophysiology and Clinical Medicine,2002,22 (2):119121.
[14] Andrew D Griffiths,Samuel C Williams,Oliver Hartley.Isolation of high affinity human antibodies directly from large synthetic repertoires.The EMBO Journal,1994,13(14 ):32453260.
[15] Hawkins R E,Russell S J,Winter G J.Selection of phage antibodies by binding affinity.Mimicking affinity maturation.J Mol Biol,1992,226:889896.
[16] Helena Persson,Henrik Wallmark,Anne Ljungars,et al.In vitro evolution of an antibody fragment population to find highaffinity hapten binders.Protein Engineering,Design & Selection,2008,21(8 ):485493.
[17] 汪保安,王琰.基因工程抗体的体外亲和力成熟.海军总医院学报,2003,16(4):222226. Wang B A,Wang Y.Journal of Naval General Hospital of PLA,2003,16(4):222226.
[18] Hermann Gram,Lorianne Marconi,Carlos F.Barbas,et al.In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library.Proc Natd Acad Sci USA,1992,89:35763580.
[19] 吴小平,阎锡蕴.噬菌体抗体库技术制备高亲和力人抗体.中国生物工程杂志,2002,22 (3):2932. Wu X P,Yan X Y.China Biotechnology,2002,22 (3):2932.
[20] Kramer K.Evolutionary affinity and selectivity optimization of a pesticideselective antibody utilizing a haptenselective immunoglobulin repertoire.Environ Sci Technol,2002,36:48924898.
[21] 胡晓林,张春明.基因工程抗体亲和力成熟的策略.免疫学杂志,2006,22(6):702704. Hu X L,Zhang C M.Journal of Immunology,2006,22(6):702704.
[22] 陈晓穗,汪保安,周丽君,等.热点突变法提高人源抗TNF2α抗体的亲和力.中华微生物学和免疫学杂志,2004,24(8):644648. Chen X S,Wang B A,Zhou L J,et al.Chin J Microbiol Immunol,2004,24(8):644648.
[23] Helena Persson,Johan Lantto ,Mats Ohlin.A focused antibody library for improved hapten recognition.J Mol Biol,2006,357,607620.
[24] 汪保安,陈晓穗 ,王琰.CDR3 突变提高抗TNF2α Fab 段的亲和力.免疫学杂志,2005,21(5):388392. Wang B A,Chen X S,Wang Y.Journal of Immunology,2005,21(5):388392.
[25] Patrick Chames,Ste′phane Coulon,Daniel Baty.Improving the affinity and the fine specificity of an anticortisol antibody by parsimonious mutagenesis and phage display.Journal of Immunology,1998,161: 54215429. |