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| Progress in Studies of DNA Methylation and Gene Expression Regulation |
| SHI Yu-jie1, LI Qing-he2, LIU Xiao-hui1 |
1. Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China;
2. College of Biological Sciences, China Agricultural University, Beijing 100193, China |
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Abstract Epigenetic modifications refer to heritable changes that do not alter the DNA sequences which occur on cytosines and histones, including DNA methylation, histone modifications, chromatin remodeling and non-coding RNAs. Epigenetic regulation is a senior means that regulating gene expression. As an important epigenetic modification, DNA methylation is involved in gene expression regulation, transposon silencing, genomic imprinting, X chromosome inactivation and tumorigenesis. The study on genome-wide DNA methylation is in progress accompanying the advancement of research technologies, and DNA methylome of several organisms and cell types had been reported. Genome-wide study on DNA methylation facilitates understanding the characteristics and functions of DNA methylation, and also the regulatory role of DNA methylation. Here we reviewed the recent progress in DNA methylation and gene expression regulation studies, including DNA methylation distribution patterns in the genome and the relationship with gene transcription.
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Received: 11 March 2013
Published: 25 July 2013
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