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中国生物工程杂志

China Biotechnology
China Biotechnology  2012, Vol. 32 Issue (05): 91-96    DOI:
    
Recent Development of Molecular Targeted Cancer Drugs Targeted EGFR
YANG Ya-qiong, LI Zong-hai
State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032,China
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Abstract  

With the progress of molecular biology, there is a growing number of molecular targeted cancer drugs have been used in clinical to treat of malignant tumors. Molecular targeted therapy is also known as "biological missile", and has become the fourth treatment methods in addition to surgery, radiotherapy and chemotherapy. Compared with traditional chemotherapy drugs, the advantages of molecular targeted drugs are specificity, efficacy and less side effects. Molecular targeted drugs can be divided into two classes according to the nature: monoclonal antibodies such as cetuximab and small molecule inhibitors with single target or multiple targets such as gefitinib. The epidermal growth factor receptor (EGFR) has been found that it contributes to tumor cell survival, proliferation, and motility. Overexpression and mutation of the EGFR gene are the most common mechanisms by which EGFR exerts influence on tumorigenesis. Therefore, EGFR has been successfully targeted for cancer therapy. The latest clinical research of the molecular targeted drugs have been listed targeted epidermal growth factor receptor (EGFR).



Key wordsMolecular targeted drugs      EGFR      Monoclonal antibodies      TKI     
Received: 10 January 2012      Published: 25 May 2012
ZTFLH:  R73-36  
Cite this article:

YANG Ya-qiong, LI Zong-hai. Recent Development of Molecular Targeted Cancer Drugs Targeted EGFR. China Biotechnology, 2012, 32(05): 91-96.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2012/V32/I05/91


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