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中国生物工程杂志

China Biotechnology
China Biotechnology  2012, Vol. 32 Issue (04): 76-82    DOI:
    
Resent Advances on Phosphoproteomics Researches of Mammalian Sperm Capacitation
ZHANG Yuan-yuan, HU Qi-meng, WANG Liang-liang, LI Xin-hong
Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
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Abstract  

Studies on protein expression, modification and interaction have become important in proteomics in the post-genomics era. Phosphorylation/dephosphorylation of proteins is the main mechanism of signal transduction and regulation of enzymes in sperm cells, what’s more, it plays a key role during the sperm-egg recognition and fertilization process. Researches about function of phosphorylated proteins contribute to the understanding of the molecular mechanism of sperm capacitation, hyperactive motility and acrosome reaction process. The progress in the researches of mammalian sperm phosphoproteomics was reviewed that include the phosphoproteomics technology, phosphorylated proteins identification and quantitation, function analysis benefits in finding new important fertilization related biological markers and revealing the sperm development, reproductive potential changes and molecular mechanism of fertilization.



Key wordsSperm      Phosphoproteomics      Mammalian     
Received: 21 December 2011      Published: 25 April 2012
ZTFLH:  Q5  
Cite this article:

ZHANG Yuan-yuan, HU Qi-meng, WANG Liang-liang, LI Xin-hong. Resent Advances on Phosphoproteomics Researches of Mammalian Sperm Capacitation. China Biotechnology, 2012, 32(04): 76-82.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2012/V32/I04/76


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