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中国生物工程杂志

China Biotechnology
China Biotechnology  2016, Vol. 36 Issue (9): 59-74    DOI: 10.13523/j.cb.20160908
    
Research Progress of Long Non-coding RNAs
DU Jing-jing, TAN Zhen-dong, LIU Chen-dong, WU Xiao-qiao, ZHANG Pei-wen, ZHANG Shun-hua, ZHU Li
College of Animal Science and Technology, Chengdu 611130, China
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Abstract  

Long non-coding RNAs (LncRNAs) are RNAs that larger than 200bp, and cannot encode proteins. Additionally, lncRNAs are badly conserved among different species, but have strong tissue specificity and temporal specificity. Recently, more and more evidences showed that lncRNAs are involved in a wide range of biological functions, including RNA biogenesis and processing, transcription regulation, chromatin modification, etc. by binding special budget proteins or as a ceRNA. However, the structure of lncRNA is very complex, and the research process of lncRNA's functionis very slowly, until now a detailed classification of lncRNA has not been done. Current knowledge of the general characteristics, categories, mechanisms, websites, and methods of lncRNA, and the proved relationship between lncRNA and cancer were reviewed, in order to provide reference for further studying the role of lncRNA.



Key wordsCategories      Cancer      lncRNA      Non-coding RNA      Functions     
Received: 01 February 2016      Published: 16 March 2016
ZTFLH:  Q522  
Cite this article:

DU Jing-jing, TAN Zhen-dong, LIU Chen-dong, WU Xiao-qiao, ZHANG Pei-wen, ZHANG Shun-hua, ZHU Li. Research Progress of Long Non-coding RNAs. China Biotechnology, 2016, 36(9): 59-74.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20160908     OR     https://manu60.magtech.com.cn/biotech/Y2016/V36/I9/59

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