Self-assembled Peptide Nanofiber Scaffolds Induce Bone Marrow Mesenchymal Stem Cells Directional Differentiation

China Biotechnology

2012, Vol. 32

Issue (02): 100-106 DOI:

Self-assembled Peptide Nanofiber Scaffolds Induce Bone Marrow Mesenchymal Stem Cells Directional Differentiation

HE Ding-wen, XU Yan-jie, LIAO Xin-geng, YIN Ming

The Second Affiliated Hospital of NanChang University, Nanchang 330006,China

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Abstract

Tissue engineering is a new idea of the modern reconstruction medicine. Biological scaffold and seed cells are two important elements for this new technology. Self-assembled peptides nanofiber scaffolds(SAPNS) are amphiphilic peptides,These peptides self-assemble into a new type of scaffold which has three-dimensional network structure under certain conditions. Its Properties such as structure, biological function, mechanics are similar to native extracellular matrix(ECM), and its internal functionalized modifications of epitope present in high concentrations on surface of nano-fiber and high- efficient selectively regulate the biological behavior of seed cells. Seed cells is the necessary condition for successful organization regeneration. Bone mesenchymal stem cells (BMSCs),due to its strong self-renewal and multiplex differentation potential,is the best candidate cell for tissue engineering. In vitro experiments showed that these specific functionalized modified of SAPNS can promote adhesion, proliferation, migration and directional differentiation of BMSCs with/without auxiliary factor.In vivo animal models found that the combination of SAPNS and BMSCs build up tissue engineering grafts can repair organic structure and function of the defect sites,so it have a good prospect in the restoration medicine. A review of SAPNS,self-assembled,BMSCs and directional differentiation was given.

Key words： Self-assembled peptides nanofiber scaffolds Self-assemble BMSCs directional differentiation

Received: 26 October 2011 Published: 25 February 2012

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HE Ding-wen, XU Yan-jie, LIAO Xin-geng, YIN Ming. Self-assembled Peptide Nanofiber Scaffolds Induce Bone Marrow Mesenchymal Stem Cells Directional Differentiation. China Biotechnology, 2012, 32(02): 100-106.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2012/V32/I02/100

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