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| Study on Cell Compatibility of Magnesium Alloy Covered with Tricalcium Phosphate |
| FU Yu-ping1, GUO Lei1, GUAN Jun-lin1, ZHAO Jie1, ZHAO Yan-gang1, TAN Li-li2, YANG Ke2 |
1. Department of Orthopedic Surgery, the First Affiliated Hospital, China Medical University, Shenyang 110001, China;
2. Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China |
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Abstract The magnesium alloy (Mg-AI-Zn) covered with tricalcium phosphate (β-TCP) was electrosynthesized and evaluated its surface characteristics and biocompatibility. The β-TCP-Mg-AI-Zn has been prepared by electrochemistry, whereas the surface structure and spectrum analysis of material were measured. The osteoblasts from mice skull were cultured with magnesium alloys in vitro, and the cell proliferation and alkaline phosphatase(ALP)were detected with methyl thiazolyl tetrazolium and fluorescein isothiocyanate. The results show that the β-TCP-Mg-AI-Zn surface was porosity and high content of magnesium, calcium and phosphorus elements. The cell proliferation and the activity of osteoblasts were increased after cultured 24 h or 48 h with the β-TCP-Mg-AI-Zn (P＜0.05). Therefore, covering with β-TCP has improved surface properties and cell compatibility in vitro. The magnesium alloy covered with β-TCP would be a new biomedical material.
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Received: 18 October 2011
Published: 25 February 2012
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