[1] Nusslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature,1980,287(5785):795-801.
[2] McCrea P D, Turck C W, Gumbiner B. A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science,1991,254(5036):1359-1361.
[3] Megy S, Bertho G, Gharbi-Benarous J, et al. Solution structure of a peptide derived from the oncogenic protein beta-Catenin in its phosphorylated and nonphosphorylated states. Peptides,2005,26(2):227-241.
[4] Stadeli R, Hoffmans R, Basler K. Transcription under the control of nuclear Arm/beta-catenin. Curr Biol,2006,16(10):378-385.
[5] Xu W, Kimelman D. Mechanistic insights from structural studies of beta-catenin and its binding partners. J Cell Sci,2007,120( 19):3337-3344.
[6] Weis W I, Nelson W J. Re-solving the cadherin-catenin-actin conundrum. J Biol Chem,2006,281(47):35593-35597.
[7] Kimelman D, Xu W. beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene,2006,25(57):7482-7491.
[8] Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer,2008,8(5):387-398.
[9] Fang D, Hawke D, Zheng Y, et al. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem,2007,282(15):11221-11229.
[10] Lucero O M, Dawson D W, Moon R T, et al. A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep,2010,12(5):314-318.
[11] Caspi M, Zilberberg A, Eldar-Finkelman H, et al. Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner. Oncogene,2008,27(25):3546-3555.
[12] Tycko B,Li C M,Buttyan R. The Wnt/beta-catenin pathway in Wilms tumors and prostate cancers. Curr Mol Med,2007,7(5):479-489.
[13] Yao H,Ashihara E,Maekawa T. Targeting the Wnt/beta-catenin signaling pathway in human cancers. Expert Opin Ther Targets,2011,15(7):873-887.
[14] Moon R T, Bowerman B, Boutros M, et al. The promise and perils of Wnt signaling through beta-catenin. Science,2002,296(5573):1644-1646.
[15] Nelson W J, Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science,2004,303(5663):1483-1487.
[16] Kuhl M, Sheldahl L C, Park M, et al. The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet,2000,16(7):279-283.
[17] Weston C R, Davis R J. The JNK signal transduction pathway. Curr Opin Genet Dev,2002,12(1):14-21.
[18] Ying Y, Tao Q. Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers. Epigenetics,2009,4(5):307-312.
[19] Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer,2008,8(5):387-398.
[20] Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci,2003,116(13):2627-2634.
[21] Fukutomi T, Zhou Y, Kawai S, et al. Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatology,2005,41(5):1096-1105.
[22] Lian Z, Liu J, Li L, et al. Enhanced cell survival of Hep3B cells by the hepatitis B x antigen effector, URG11, is associated with upregulation of beta-catenin. Hepatology,2006,43(3):415-424.
[23] Lade A G, Monga S P. Beta-catenin signaling in hepatic development and progenitors: which way does the WNT blow. Dev Dyn, 2011,240(3):486-500.
[24] Sodhi D, Micsenyi A, Bowen W C, et al. Morpholino oligonucleotide-triggered beta-catenin knockdown compromises normal liver regeneration. J Hepatol,2005,43(1):132-141.
[25] Myung S J, Yoon J H, Gwak G Y, et al. Wnt signaling enhances the activation and survival of human hepatic stellate cells. FEBS Lett,2007,581(16):2954-2958.
[26] Cheng J H, She H, Han Y P, et al. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol,2008,294(1):G39-G49.
[27] Jiang F, Parsons C J, Stefanovic B. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol,2006,45(3):401-409.
[28] Zeng G, Awan F, Otruba W, et al. Wnt'er in liver: expression of Wnt and frizzled genes in mouse. Hepatology,2007,45(1):195-204.
[29] Monga S P. Role of Wnt/beta-catenin signaling in liver metabolism and cancer. Int J Biochem Cell Biol, 2011, 43(7):1021-1029.
[30] Huang H, Fujii H, Sankila A, et al. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol,1999,155(6):1795-1801.
[31] Kim M, Lee H C, Tsedensodnom O, et al. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol,2008,48(5):780-791.
[32] Cieply B, Zeng G, Proverbs-Singh T, et al. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. Hepatology,2009,49(3):821-831.
[33] Sekine S, Ogawa R, Ojima H, et al. Overexpression of alpha-methylacyl-CoA racemase is associated with CTNNB1 mutations in hepatocellular carcinomas. Histopathology,2011,58(5):712-719.
[34] Wang X H, Meng X W, Sun X, et al. Wnt/beta-catenin signaling regulates MAPK and Akt1 expression and growth of hepatocellular carcinoma cells. Neoplasma,2011,58(3):239-244.
[35] Feng Z, Fan X, Jiao Y, et al. Mammalian target of rapamycin regulates expression of beta-catenin in hepatocellular carcinoma. Hum Pathol,2011,42(5):659-668.
[36] Apte U, Thompson M D, Cui S, et al. Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology,2008,47(1):288-295.
[37] Yang W, Yan H X, Chen L, et al. Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res,2008,68(11):4287-4295.
[38] Chiba T, Zheng Y W, Kita K, et al. Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation. Gastroenterology,2007,133(3):937-950.
[39] Ji J, Yamashita T, Wang X W. Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. Cell Biosci,2011,1(1):4.
[40] Abdel A M T, El A M F, Atta H M, et al. Efficacy of mesenchymal stem cells in suppression of hepatocarcinorigenesis in rats: possible role of wnt signaling. J Exp Clin Cancer Res,2011,30:49.
[41] Zulehner G, Mikula M, Schneller D, et al. Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence. Am J Pathol,2010, 176(1):472-481.
[42] Inagawa S, Itabashi M, Adachi S, et al. Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival. Clin Cancer Res,2002,8(2):450-456.
[43] Liu L, Zhu X D, Wang W Q, et al. Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis. Clin Cancer Res,2010, 16(10):2740-2750.
[44] Cha M Y, Kim C M, Park Y M, et al. Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. Hepatology,2004,39(6):1683-1693.
[45] Dal Bello B,Rosa L,Campanini N, et al. Glutamine synthetase immunostaining correlates with pathologic features of hepatocellular carcinoma and better survival after radiofrequency thermal ablation. Clin Cancer Res,2010,16(7):2157-2166.
[46] Hsieh A, Kim H S, Lim S O, et al. Hepatitis B viral X protein interacts with tumor suppressor adenomatous polyposis coli to activate Wnt/beta-catenin signaling. Cancer Lett,2011,300(2):162-172.
[47] Colnot S, Decaens T, Niwa-Kawakita M, et al. Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomas. Proc Natl Acad Sci U S A,2004, 101(49):17216-17221.
[48] Harada N,Oshima H,Katoh M, et al. Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations. Cancer Res,2004,64(1):48-54.
[49] Wolfe A, Thomas A, Edwards G, et al. Increased Activation of the Wnt/{beta}-Catenin Pathway in Spontaneous Hepatocellular Carcinoma Observed in Farnesoid X Receptor Knockout Mice. J Pharmacol Exp Ther,2011,338(1):12-21.
[50] Zhang X F, Tan X, Zeng G, et al. Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Hepatology,2010,52(3):954-965.
[51] Thompson M D, Wickline E D, Bowen W B, et al. Spontaneous repopulation of beta-catenin null livers with beta-catenin positive hepatocytes after chronic murine liver injury. Hepatology,2011, (Epub ahead of print).
[52] Kavak E, Najafov A, Ozturk N, et al. Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. Cell Signal,2010,22(10):1523-1535.
[53] Nambotin S B, Wands J R, Kim M. Points of therapeutic intervention along the wnt signaling pathway in hepatocellular carcinoma. Anticancer Agents Med Chem,2011,11(6):549-559.
[54] Noda T, Nagano H, Takemasa I, et al. Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to interferon-alpha/5-fluorouracil combination therapy for hepatocellular carcinoma. Br J Cancer,2009,100(10):1647-1658.
|