The research advances of function and structure of Somatomedin B domain

China Biotechnology

2006, Vol. 26

Issue (0): 177-181 DOI:

The research advances of function and structure of Somatomedin B domain

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Abstract

Abstract Somatomedin B domains in different proteins have different functions, including its binding to PAI-1 and to integrins, mediation of homodimerization of protein and inhibition of trypsin activation, et al. SMB domain contains 8 consensus cystines animo acids X4CX3CX9CXCX3CX5CCX5CX5 and the RGD sequence in C-terminal. The disulfide bonds of the recombinant SMB and the SMB isolated by digesting native protein by NMR or protein crystal are not identical.

Key words： SMB domain function disulfide bonds RGD

Received: 28 December 2005 Published: 15 June 2006

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. The research advances of function and structure of Somatomedin B domain. China Biotechnology, 2006, 26(0): 177-181.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2006/V26/I0/177

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