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Application of Synthetic Biology in Research and Development of the Secondary Metabolites from Streptomyces |
LI Xiao-mei, LIN Chun-yan, PANG Ai-ping, LI Xiao-bo, ZHAO Guang-rong |
Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University; Key Laboratory of Systems Bioengineering, Ministry of Education, SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, China |
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Abstract Streptomyces, a kind of Gram-positive bacteria, can produce lots of secondary metabolites which are widely used in the pharmaceutical industry, food processing and agriculture production. Genetic manipulation for Streptomyces is the foundation for the discovery and development of new secondary metabolites. The emergence of synthetic biology opens a new window for researches in Streptomyces and achievements on cloning and assembly of the biosynthetic gene cluster, the chassis cell design and the fitness were reviewed.
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Received: 04 January 2015
Published: 25 April 2015
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