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| CD4+CD25+ Regulatory T cells、IL-2 and Immune Tolerance |
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Abstract More and more research proved that CD4+CD25+ regulatory T cells (Treg cells) play an important role in immune tolerance in these years. Known as a T cell growth factor, Interleukin-2 (IL-2) regulated the immune tolerance induced by Treg cells. IL-2 sustained the activity of Treg cells both in thymus and periphery while it was dispensable for the development of Treg cells in thymus. In addition, IL-2 signal affected the function of Treg cells and maintained their competitive fitness. Therefore, CD4+CD25+ Treg cells and IL-2 formed an immune network to regulate the processes of immune response, immune tolerance and autoimmune homeostasis.
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Received: 26 July 2006
Published: 25 November 2006
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