Progress and Technology in Mammary Gland Bioreactor of Transgenic Animals

doi:10.13523/j.cb.20150214

China Biotechnology

2015, Vol. 35

Issue (2): 92-98 DOI: 10.13523/j.cb.20150214

Progress and Technology in Mammary Gland Bioreactor of Transgenic Animals

LIANG Zhen-xin¹, YIN Fu-qiang¹, LIU Qing-you², LI Li¹

1. Guangxi Medical University, Nanning 530021, China;
2. Guangxi University, Nanning 530004, China

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Abstract

Production of human serum albumin (hSA), fibrinogen (hFIB), human protein c (hPC), human blood clotting factor VIII (HF-VIII)and human blood clotting factor (hF-IX) by mammary gland bioreactor of transgenic has great market potential and is widely used in medical areas. A comprehensive review was made on the advantages, selection of target genes, construction of vector, genetic engineering technology, the application of recombinant proteins in cancer treatment, problems and prospects of mammary gland bioreactor of transgenic animals, in order to contribute to the study on transgenic animal bioreactors. Also the possibility of high level expression of human recombinant proteins by the method of CRISPR-Cas gene targeting was discussed.

Key words： Mammary gland bioreactor Vector construction Transgenic technology Bio-pharmacy

Received: 03 December 2014 Published: 25 February 2015

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Cite this article:

LIANG Zhen-xin, YIN Fu-qiang, LIU Qing-you, LI Li. Progress and Technology in Mammary Gland Bioreactor of Transgenic Animals. China Biotechnology, 2015, 35(2): 92-98.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20150214 OR https://manu60.magtech.com.cn/biotech/Y2015/V35/I2/92

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