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| Research Progress in Aquaculture Ghost Vaccines |
| JIANG Na, XING Wei, MA Zhi-hong, LI Tie-liang, LUO Lin |
| Beijing Fisheries Research Institute, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100068, China |
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Abstract Bacterial ghost, a novel inactivated non-denatured bacterium, is intact bacterial envelope which is lysised by the lysis gene E of PhiX174. Bacterial ghost has been researched as fish bacteria vaccine just in recent 8 years. It not only has high biological safety, but also can induce humoral and cellular immunity. So bacterial ghost is possible to be used in oral immunization and has a unique advantage in fish vaccine. Much more attention has been paid on ghost being used as a recombinant vaccine or drug delivery system. This paper summarizes the international latest developments in fish bacterial ghost vaccine, discusses their immune response and protective effect in different immunization ways using different strategies.
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Received: 24 July 2013
Published: 25 November 2013
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