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| Fermentation Optimization Directed by Physiological Parameter Respiratory Quotient |
| WANG Ping1,2, WANG Ze-Jian2, ZHANG Si-liang2 |
1. Hebei Medical University, Shijazhuang 050017, China;
2. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China |
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Abstract Online measurement of process parameters play a fundamental role in optimization and control of fermentation process engineering. Respiratory quotient(RQ) is the response of intracellular microscopic flow on global metabolic parameters, which reflect the utilization of substrates, product and by-products synthesis, and the changes of metabolic pathways and flux in microbial cultivation. The optimal controlling strategies of fermentation process based on the combination of micro-intracellular metabolism and macro-physiological parameter RQ in several industrial products production were investigated. RQ, measured by exhaust gas analysis online, is a crucial factor in optimization of the intracellular metabolic pathway flux through the regulation of global metabolic parameters and improvement of the yields of target product.
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Received: 03 December 2012
Published: 25 February 2013
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