|
|
|
| Progress in the Study of Microbial Signal Molecule Degradation Enzymes |
| ZHAO Jing, QUAN Chun-shan |
| College of Life Science, Dalian Nationalities University, Key Laboratory of Biochemical Engineering (State Ethnic Affairs Commission-Ministry of Education), Dalian Nationalities University, Dalian 116600, China |
|
|
|
Abstract The communication mechanism adopted by microbial cells is known as quorum sensing. Quorum sensing plays essential roles in coordinating biological functions of microbes, including virulence and biofilm formation. Microbes can release, detect and respond to special signal molecules, thus regulating the expression of target genes. Inhibition of signal molecules accumulation would help interfere quorum sensing system, as well as disrupt biological functions of microbes. Among signal molecules, acylhomoserine lactones(AHLs)have been well demonstrated. A range of AHL-degradation enzymes have been identified, mainly divided into two categories: AHL lactonase and AHL acylase. Detailed review regarding sources, screening methods, purification technologies, properties, mechanisms and application in disease control of AHL degradation enzymes has been presented. Study on signal degradation enzymes help to elucidate regulation mechanism of quorum sensing and provide new strategy for microbial disease prevention.
|
|
Received: 24 August 2012
Published: 25 December 2012
|
|
|
|
|
[1] Dong Y H, Zhang L H. Quorum sensing and quorum-quenching enzymes. The Journal of Microbiology, 2005, 43(Spec): 101-109.
[2] 周玥, 刘小锦, 朱晨光, 等. 细菌中群体感应调节系统, 微生物学报, 2004, 44(1):122-125. Zhou Y, Liu X J, Zhu C G, et al. Quorum sensing in bacteria. Acta Microbiologica Sinica, 2004, 44(1):122-125.
[3] 郭秀春, 郑 立, 周文辉, 等. 海洋微生物中二酮哌嗪类化合物的研究进展. 微生物学通报, 2009, 36(10): 1596-1603. Guo X C, Zheng L, Zhou W H, et al. Research advance on diketopiperazines produced by marine microorganism. Microbiology, 2009, 36(10): 1596-1603.
[4] 车付彬, 徐楠, 陈江汉. 病原真菌中群体感应现象研究进展. 第二军医大学学报, 2009, 30(4):447-449. Che F B, Xu N, Chen J H. The development of quorum sensing phenomenon in pathogenic fungi. Academic Journal of Second Military Medical University, 2009, 30(4):447-449.
[5] Ren D C, Givskov M, Rasmussen T B, et al. Quorum-sensing inhibitory compounds. control of biofilm infections by signal manipulation. Springer Series on Biofilms, 2008,2:51-77.
[6] Yates E A, Philipp B, Buckley C, et al. N-Acylhomoserine lactones undergo lactonolysis in a pH, temperature, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa. Infection and Immunity, 2002, 70(10), 5635-5646.
[7] Bainton N J, Stead P, Chhabra S R, et al. N-(3-Oxohexanoyl)-L-homoserine lactone regulates carbapenem antibiotic production in Erwinia carotovora. Biochemical Journal, 1992, 288(Pt 3): 977-1004.
[8] D’Angelo-Picard C, Faure D, Penot I, et al. Diversity of N-acyl homoserine lactone-producing and-degrading bacteria in soil and tobacco rhizosphere. Environmental Microbiology, 2005, 7 (11): 1796-1808.
[9] Romero M, Martin-Cuadrado A, Roca-Rivada A, et al. Quorum quenching in cultivable bacteria from dense marine coastal microbial communities. FEMS Microbiology Ecology, 2011, 75(2): 205-217.
[10] Xu F, Byun T, Dussen H, et al. Degradation of N-acylhomoserine lactones, the bacterial quorum-sensing molecules, by acylase. Journal of Biotechnology, 2003, 101(1): 89-96.
[11] Roche D M, Byers J T, Smith D S, et al. Communications blackout? Do N-acylhomoserinelactone-degrading enzymes have any role in quorum sensing? Microbiology, 2004, 150(7): 2023-2028.
[12] Czajkowski R, Jafra S. Quenching of acyl-homoserine lactone-dependent quorum sensing by enzymatic disruption of signal molecules. Acta Biochimica Polonica, 2009, 56(1): 1-16.
[13] Czajkowski R, Krzyzanowska D, Karczewska J, et al. Inactivation of AHLs by Ochrobactrum sp. A44 depends on the activity of a novel class of AHL acylase. Environmental Microbiology Reports, 2011, 3(1): 59-68.
[14] Ulrich R L. Quorum quenching: enzymatic disruption of n-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis. Applied and Environmental Microbiology, 2004, 70(10): 6173-6180.
[15] Park S Y, Lee S J, Oh T K, et al. AhlD, an N-acylhomoserine lactonase in Arthrobacter sp., and predicted homologues in other bacteria. Microbiology, 2003, 149(Pt 6): 1541-1550.
[16] Dong Y H, Gusti A R, Zhang Q, et al. Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus species. Applied and Environmental Microbiology, 2002, 68(4): 1754-1759.
[17] Park S Y, Kang H O, Jang H S, et al. Identification of extracellular N-acylhomoserine lactone acylase from a Streptomyces sp. and its application to quorum quenching. Applied and Environmental Microbiology, 2005, 71(5):2632-2641.
[18] Wang W Z, Morohoshi T, Ikenoya M, et al. AiiM, a novel class of N-acylhomoserine lactonase from the leaf-associated bacterium Microbacterium testaceum. Applied and Environmental Microbiology, 2010, 76(8): 2524-2530.
[19] Uroz S, Oger P M, Chapelle E, et al. A Rhodococcus qsd-A-encoded enzyme defines a novel class of large-spectrum quorum quenching lactonases. Applied and Environmental Microbiology, 2008,74(5): 1357-1366.
[20] Romero M, Diggle S P, Heeb S, et al. Quorum quenching activity in Anabaena sp. PCC7120: identification of AiiC, a novel AHL-acylase. FEMS Microbiology Letters, 2008, 280(1): 73-80.
[21] Kang B R, Lee J H, Ko S J, et al. Degradation of acylhomoserine lactone molecules by Acinetobacter sp. strain C1010. Canadian Journal of Microbiology, 2004, 50(11): 935-941.
[22] Park S Y, Hwang B J, Shin M H, et al. N-acylhomoserine lactonase-producing Rhodococcus spp.with different AHL-degrading activities. FEMS Microbiology Letters, 2006, 261(1): 102-108.
[23] Uroz S, Chhabra S R, Cámara M, et al. N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities. Microbiology, 2005, 151(10), 3313-3322.
[24] Uroz S, D’Angelo-Picard C, Carlier A, et al. Novel bacteria degrading N-acylhomoserine lactones and their use as quenchers of quorum-sensing-regulated functions of plant-pathogenic bacteria. Microbiology, 2003, 149(8), 1981-1989.
[25] Uroz S, Oger P, Chhabra S R, et al. N-acyl homoserine lactones are degraded via an amidolytic activity in Comamonas sp. strain D1. Archives of Microbiology, 2007, 187(3): 249-256.
[26] Lin Y H, Xu J L, Hu J Y, et al. Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes. Molecular Microbiology, 2003, 47(3): 849-860.
[27] Yang F, Wang L H, Wang J, et al. Quorum quenching enzyme activity is widely conserved in the sera of mammalian species. FEBS Letters, 2005, 579(17): 3713-3717
[28] Huang J J, Han J I, Zhang L H, et al. Utilization of acyl-homoserine lactone quorum signals for growth by a soil Pseudomonad and Pseudomonas aeruginosa PAO1. Applied and Environmental Microbiology, 2003, 69(10): 5941-5949.
[29] Yin X T, Xu L, Fan S S, et al. Isolation and characterization of an AHL lactonase gene from Bacillus amyloliquefaciens. World Journal of Microbiology and Biotechnology, 2010, 26(8): 1361-1367.
[30] Morohoshi T, Nakazawa S, Ebata A, et al. Identification and characterization of N-acylhomoserine lactone-acylase from the fish intestinal Shewanella sp. strain MIB015. Bioscience, Biotechnology, and Biochemistry. 2008, 72 (7): 1887-1893.
[31] 邱健, 贾振华, 李承光, 等. 细菌群体感应猝灭酶的研究进展, 微生物学通报, 2006, 33(4): 139-143. Qiu J, Jia Z H, Li C G, et al. Advance on bacterial quorum-quenching enzymes. Microbiology, 2006, 33(4): 139-143.
[32] Steindler L, Venturi V. Detection of quorum-sensing N-acyl homoserine lactone signal molecules by bacterial biosensors. FEMS Microbiology Letters, 2007, 266(1): 1-9.
[33] Leadbetter J R, Greenberg E P. Metabolism of acyl-homoserine lactone quorum-sensing signals by Variovorax paradoxus. Journal of Bacteriology, 2000,182(24): 6921-6926.
[34] Chan K G, Yin W F, Sam C K, et al. A novel medium for the isolation of N-acylhomoserine lactone-degrading bacteria. Journal of Industrial Microbiology and Biotechnology, 2009,36(2): 247-251.
[35] Dong Y H, Wang L H, Xu J L, et al. Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature, 2001, 411(6839): 813-817.
[36] Wang L H, Weng L X, Dong Y H, et al. Specificity and enzyme kinetics of the quorum-quenching N-acyl homoserine lactone lactonase. Journal of Biological Chemistry, 2004, 279(14): 13645-13651.
[37] Thomas P W, Stone E M, Costello A L, et al. The quorum-quenching lactonase from Bacillus thuringiensis is a metalloprotein. Biochemistry, 2005, 44(20): 7559-7569.
[38] Chen R D, Zhou Z G, Cao Y N, et al. High yield expression of an AHL-lactonase from Bacillus sp. B546 in Pichia pastoris and its application to reduce Aeromonas hydrophila mortality in aquaculture. Microbial Cell Factories, 2010, 9: 39.
[39] Dong Y H, Xu J L, Li X Z, et al. AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97(7): 3526-3531.
[40] Defoird T,Boona N, Bossierb P, et al. Disruption of bacterial quorum sensing: an unexplored strategy to fight infections in aquaculture. Aquaculture, 2004, 240(1-4): 69-88.
[41] Chan K G, Wong C S, Yin W F, et al. Rapid degradation of N-3-oxo-acylhomoserine lactones by a Bacillus cereus isolate from Malaysian rainforest soil. Antonie Van Leeuwenhoek, 2010, 98(3):299-305.
[42] Kim M H, Choi W C, Kang H O, et al. The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102(49): 17606-17611.
[43] Liu D, Thomas P W, Momb J, et al. Structure and specificity of a quorum-quenching lactonase (AiiB) from Agrobacterium tumefaciens. Biochemistry, 2007, 46(42):11789-11799.
[44] Dong Y H, Wang L H, Zhang L H. Quorum-quenching microbial infections: mechanisms and implications. Philosophical Transactions of the Royal Society of London, Series B, 2007, 362(1483):1201-1211.
[45] Reimmann C, Ginet N, Michel L, et al. Genetically programmed autoinducer destruction reduces virulence gene expression and swarming motility in Pseudomonas aeruginosa PAO1. Microbiology, 2002, 148(4): 923-932. |
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
