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| Studies on the Properties of Biomacromolecules under Molecular Crowded Conditions |
| ZHANG Yu-jiao1, TANG Qian1, CAO Hong-yu1, ZHENG Xue-fang1,2 |
1. School of Life Science and Biotechnology, Dalian University, Dalian 116622, China;
2. Liaoning Key Lab of Bio-organic Chemistry, Dalian University, Dalian 116622, China |
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Abstract Living cells contain a variety of biomolecules, they play their physiological functions in different concentrations, which is often neglected in vitro studies. With the molecular crowding theory put forward, the addition of crowding agents in vitro is valued by more and more biologists and chemists, many research results show that the molecular crowding has effects on the properties of the biomolecules. The properties and functions of biomolecules from the effects of molecular crowding on protein folding, aggregation, enzymatic activity, the nucleic acids molecular structure and properties under the crowding conditions were discussed, to provide more references for the further research.
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Received: 03 August 2012
Published: 25 December 2012
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