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Progress in the study of Ser/Thr kinase Plk1 |
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Abstract Polo-like kinase 1(Plk1) play critical roles during multiple stages of cell cycle progression. Plk1 contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region that contains two Polo-boxes. Plk1 gene and protein expression has been proposed as a new prognostic marker for many types of malignancies, and Plk1 is a potential target for cancer therapy.
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Received: 20 December 2006
Published: 25 May 2007
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