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Abstract Lymphocyte function associated antigen1 (LFA-1) is a member of integrin family, that plays an important role in the adhesion of lymphocytes with other cells and matrix. To investigate the role of LFA1 in collageninduced arthritis (CIA), the incidence of CIA, histological and radiological assessments in the LFA-1 deficient (LFA-1 -/-) mice and control mice were examined. LFA-1 -/- mice and control mice were immunized with 100μg collagen type II(CII) emulsified with an equal volume of Freund’s complete adjuvant (CFA), followed by the booster injection of the same amount of CII in CFA on day 21. Then, clinical, histological and radiological assessments were done. It showed that 57% control mice developed arthritis and apparently changed in the histological and radiological assessment, whereas the all of LFA-1-/-mice had the normal histological and radiographic response and none developed arthritis. These results suggeste that LFA1 is indispensable for the onset of CIA.
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Received: 18 November 2005
Published: 25 February 2006
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