Generation of Transgenic Mice with Cardiac-specific overexpressing heat shock protein 27

China Biotechnology

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Generation of Transgenic Mice with Cardiac-specific overexpressing heat shock protein 27

Liu Li xiao-jin zhang su－rong jiang yun-lin cheng

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Abstract Increased reactive oxygen species (ROS) formation and by which in turn promotes cardiomyocytes apoptosis is associated with the pathogenesis and progression of various cardiac diseases. Small heat shock protein 27(Hsp27) could protect different cells from oxidative damage. By using tissue nonspecific overexpression Hsp 27 transgenic model, other investigators demonstrated that Hsp27 suppressed successfully kainate-induced seizures and hippocampal cell death in intact transgenic mice, and attenuated mimic ischemia/reperfusion injury in Langendorff-perfused isolated mice heart. As there are complicated and long distance neuro-humoral regulation associated with the development of cardiac diseases, it is better to choose a cardiac-specific overexpression transgenic model to study the effects of Hsp27 in hearts in vivo.

Key words： Heat shock protein 27 cardiac-specific overexpression Gene transfection

Received: 20 June 2006 Published: 25 November 2006

Corresponding Authors: Liu Li

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	Liu Li xiao-jin zhang su－rong jiang yun-lin cheng
	Liu Li xiao-jin zhang su－rong jiang yun-lin cheng
	Liu Li xiao-jin zhang su－rong jiang yun-lin cheng
	Liu Li xiao-jin zhang su－rong jiang yun-lin cheng

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Liu Li xiao-jin zhang su－rong jiang yun-lin cheng . Generation of Transgenic Mice with Cardiac-specific overexpressing heat shock protein 27. China Biotechnology, 2006, 26(11): 29-32.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2006/V26/I11/29

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