中国生物工程杂志

Objective: to evaluate biological safety of HAP/AZ31B as implanted material. Methods: HAP/AZ31B biomaterial was prepared by cathodic electrodeposition with constant voltage technique, and then biocompatibility was assessed. The corrosion of surface was detected by spectrum analysis. Results: HAP/AZ31B had no mutagenesis and toxic effect. Serious inflammatory reaction was not induced. The corrosion velocity of HAP/AZ31B was slower. The micronucleus frequency and hemolysis of HAP/AZ31B leaching liquor was 4.4‰ and 0.25%, respectively. Conclusion: HAP/AZ31B had excellent biological safety and biocompatibility, which would be a new degradable and biomedical material.