Research Progress in Accessory Gene Regulatory System of Staphylococcus aureus

China Biotechnology

2008, Vol. 28

Issue (6): 93-99 DOI:

Research Progress in Accessory Gene Regulatory System of Staphylococcus aureus

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Abstract

Staphylococcus aureus is a primary pathogen that poses a serious health threat as a consequence of multiantibiotic resistance. S. aureus can cause diverse serious diseases in humans and animals through the production of toxins, most toxin genes are positively controlled by the accessory gene regulator (agr) system which is responsible for the regulation of more than 30 virulence factors in S. aureus. The agr system which could be a useful target for drug selection is one of the most extensively studied quorum sensing systems for its potential relevance to human disease. Yet many questions regarding the agr signaling remain unsolved. Herein, we review the agr system as we currently understand them and discuss the inconsistencies of the role and fundamental mechanisms of agr in staphylococcal infections.

Key words： Staphylococcus aureus agr quorum sensing virulence resistant

Received: 18 January 2008 Published: 25 June 2008

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. Research Progress in Accessory Gene Regulatory System of Staphylococcus aureus. China Biotechnology, 2008, 28(6): 93-99.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2008/V28/I6/93

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