中国生物工程杂志

The ex vivo expansion of human hematopoietic stem cells (HSCs) is a rapidly developing area with a broad range of biomedical applications. Because the traditional static culture systems can hardly satisfy the ex vivo expansion of HSCs in a large scale, several kinds of bioreactors have been tested to culture these cells, such as perfusion chambers, stirred reactors and rotating reactors. The culture results with these bioreactors are usually much better than the static systems since the bioreactors have lots of advantages.