中国生物工程杂志

Lactobacillus, a natural treasure, has been used as a kind of probiotics for a long time. Molecular techniques are being employed to modify this Gram-positive bacterium as to better serve food industry, but compare with E.coil, this work is just initial. Recently, Lactobacillus has been developed as a vector for exogenous gene expression to prepare new probiotics. Recent 20 years, Lactobacillus vectors have been constructed and successfully induced to express proteins. As an important component in normal microbial flora in human body, Lactobacillus vectors are very promising. Here, new advances in this aspect are provided.