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中国生物工程杂志

China Biotechnology
China Biotechnology  2010, Vol. 30 Issue (05): 122-127    DOI:
    
The Advance in Long Effect Interferon Reserch
TIAN Shuo1,XU Chen2,YAO Wen-bing1
1.School of Science & Technology,China Pharmaceutical University, Nanjing 210009,China
2.Beijing TriPrime Genetic Engineering Co.Ltd.,Beijing102600,China
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Abstract  

Interferons are a class of cytokines that play key roles in the regulation of cell growth and differentiation via activation of a cascade of intracellular pathways and represented the functions of antiviral, immunomodulatory, and antiproliferative effects,which are synthesized and secreted by somatic cells of all mammalian species. Interferon alpha (IFN-α) are used in clinic to treat a variety of viral diseases and cancers. Howerver,the short circulating half-life of IFN-α necessitates frequent administration to patients which limits the broader usage. The methods of prolonging the half-life of protein drug in common use are chemical modification, albumin fusion technology, analog construction and combination with drug delivery system. Herein the method of prolonging the half-life of IFN-α in the above-mentioned of the latest research methods were reviewed.



Key wordsIFN-&alpha      half-life Site-directed mutagenesis PEGylation Albumin fusion     
Received: 29 January 2010      Published: 25 May 2010
Cite this article:

TIAN Shuo, XU Chen, TAO Wen-Bing. The Advance in Long Effect Interferon Reserch. China Biotechnology, 2010, 30(05): 122-127.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2010/V30/I05/122

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