Analysis of sequences and structures of the malate dehydrogenase isozyme

China Biotechnology

2006, Vol. 26

Issue (0): 118-122 DOI:

Analysis of sequences and structures of the malate dehydrogenase isozyme

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Abstract

Malate dehydrogenase (MDH), an essential enzyme in many pathways, has been widely distributed from a variety of sources. Multiple amino acid sequence alignments are used to study the phylogenetic relationship of the MDHs from different sources, and show that there are three kinds of MDHs. Using technologies of bioinformatics, conserved structure and domains are analyzed, including coenzyme NAD (or NADP) bonding domain, active site signature and substrate bonding domain. The relationship between mechanism of catalysis and sequences, structures of MDH are also investigated. The application of bioinformatics in the research of MDH to redesign by rational was put forward.

Key words： function malate dehydrogenase phylogenetics structure

Received: 13 March 2006 Published: 15 June 2006

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Cite this article:

. Analysis of sequences and structures of the malate dehydrogenase isozyme. China Biotechnology, 2006, 26(0): 118-122.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2006/V26/I0/118

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