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Myostatin inhibits myogenic satellite cell differentiation through down-regulating MyoD expression by Smad3 |
RUAN Jing-ling ZHEN-xin |
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Abstract Myostatin is a negative regulator of myogenesis, which inhibits myogenic cell differentiation by down-regulating MyoD expression, but the specific mechanisim is not yet completely clear. In this study we cultured the myogenic satellite cell in vitro, carried out RNAi study in which smad3 is the target gene by RNAi. The influences of Smad3 gene interference on myogenic satellite cell proliferation were studied. The changes of MyoD and Myostatin gene after smad3 gene interference in myogenic satellite cell were also studied, and the relationship of regulation among three genes was further explained. Together, this results show that myostatin inhibits myogenic cell differentiation by down-regulating MyoD expression, but this inhibition is mediated through Smad3.
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Received: 26 November 2007
Published: 25 May 2008
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