Advances of Lentiviral Vectors Design and Application

China Biotechnology

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Advances of Lentiviral Vectors Design and Application

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Abstract As an efficient gene transfer vehicle lentiviral vector has been widely used in the gene therapy research. Comparing with other retrovirus vectors, lentiviral vectors have the unique ablility of transfecting non-dividing cells and terminal differentiated cells. In addition lentiviral vectors can accommodate two or more promoters and can carry larger foreign gene insertions. Now the new generation of lentiviral vectors encoding transcriptional control sequence provides effective means for the regulation of foreign gene expression. This review summarizes the development of lentiviral vectors and its application in the gene therapy field.

Key words： tet-on/off system gene therapy lentiviral vectors transcriptional regulation

Received: 15 May 2006 Published: 25 November 2006

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Cite this article:

. Advances of Lentiviral Vectors Design and Application. China Biotechnology, 2006, 26(11): 70-75.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2006/V26/I11/70

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