A Function of Targeting Fusion Protein XE-TNFαm2 to Lead Apoptosis in Cells Infected by HIV/SIV

China Biotechnology

2009, Vol. 29

Issue (03): 9-13 DOI:

A Function of Targeting Fusion Protein XE-TNFαm2 to Lead Apoptosis in Cells Infected by HIV/SIV

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Abstract

Engineered targeting fusion protein XE-TNFαm2 was prepared.In which,XE is the second excellular domain of CXCR4,a co-receptor of HIV/SIV;TNFαm2 is a mutation protein of TNFα.Its side effect was reduced 18 fold.It has been used in clinic for cancer therapy.Our previous study indicated that one of XE-TNFαm2 functions is to kill the cells infected by HIV/SIV,but, not to kill the normal cells without HIV/SIV. The purpose in this study is that to explore whether XE-TNFαm2 could lead cell to apoptosis,as its effect mechanism.The result shows that XE-TNFαm2 only can lead the apoptosis of cells infected by SIV,but can not lead this effect on normal cells without HIV/SIV.It indicates that XE-TNFαm2 is an accurate targeting fusion protein to specifically kill cells infected by HIV/SIV,but not be able to kill normal cells without HIV/SIV.It side effect is minimized。

Received: 05 January 2009 Published: 31 March 2009

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	Articles by authors
	LU Jin-Zhi- Chen-Wei-Jing- Yang-Jing- Chen-Xiang- Jiang-Gong- Wang-Wei- Li-Chao- Tun-Gang- Huang-Yi- Tong-Wei- Cong-Zhe- Wei-Jiang- Wang-Jing-Xing- Lei-Ku-Dong

Cite this article:

LU Jin-Zhi- Chen-Wei-Jing- Yang-Jing- Chen-Xiang- Jiang-Gong- Wang-Wei- Li-Chao- Tun-Gang- Huang-Yi- Tong-Wei- Cong-Zhe- Wei-Jiang- Wang-Jing-Xing- Lei-Ku-Dong. A Function of Targeting Fusion Protein XE-TNFαm2 to Lead Apoptosis in Cells Infected by HIV/SIV. China Biotechnology, 2009, 29(03): 9-13.

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https://manu60.magtech.com.cn/biotech/ OR https://manu60.magtech.com.cn/biotech/Y2009/V29/I03/9

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