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中国生物工程杂志

China Biotechnology
China Biotechnology  2011, Vol. 31 Issue (01): 70-74    DOI:
    
Progress in the Differentiation of Stem Cells into Pancreatic β Cells
SHEN Yi-hang, ZENG Fan-yi
Department of Development Biology, Institute of Medical Science, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
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Abstract  

The differentiation of stem cells into pancreatic β cells is a promising and novel strategy for the treatment of diabetes. This method would not only avoid the complications of insulin injections, but also reduce treatment delays due to shortages of donors for pancreatic islet transplantion. The cell types shown to have at least some potential for differentiation into insulin-secreting cells include pancreatic stem progenitor cells, pancreatic duct cells, acinar cells, liver/intestinal cells, embryonic stem cells and induced pluripotent stem (iPS) cells. The methods described most often for differentiating these cells into pancreatic β cells in vitro include variations of the D'Amour protocol and the Lumelsky protocol.Recent progresses in the directed differentiation of stem cells into pancreatic β cells was summarized.



Key wordsStem cell      Directed differentiation      Pancreatic &beta      cell      Pancreatic and duodenal homeobox 1 (Pdx1)      Glucagon-like peptide 1 (GLP-1)     
Received: 06 August 2010      Published: 25 January 2011
ZTFLH:  Q254  
Cite this article:

SHEN Yi-hang, ZENG Fan-yi. Progress in the Differentiation of Stem Cells into Pancreatic β Cells. China Biotechnology, 2011, 31(01): 70-74.

URL:

https://manu60.magtech.com.cn/biotech/     OR     https://manu60.magtech.com.cn/biotech/Y2011/V31/I01/70


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