中国生物工程杂志

Mesenchymal stem cells (MSCSs) are progenitor cells of the bone marrow stroma and have capacity of multilineage differentiation. Recently, their functions of immune regulation are being addressed enthusiastically which may relate to various factors: immune molecules expressed on MSCSs surface, their biding bility to immune effect cells and their functions on immune cells. Up to now, acknowledges of the mechanisms of MSCSs immune functions are not consistent. Soluble cytokines, cell surface molecules, IDO, cell contact, cell cycle arrest and antigen presenting cells might involved in the suppression of immune system.