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Fluorescence and Release Property Research of a New Fan-shape Polyamidoamine Dendrimer with a core of glycin |
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Abstract Nowadays, the synthesis of polyamidoamine denerimers includes "solid phase synthesis" and "liquid phase synthesis". A new thought of synthesis polyamidoamine denerimer by fall together this two advantage is introduced. Having glycin as the core, a new fan-shape polyamidoamine denerimers are synthesized. The Fluorescence and Release Property are being studied too. The dendrimer were then reacted with 1- acetic-5-fluorouracil to form dendrimer-5FU conjugates. Hydrolysis of the conjugates in a phosphate buffer solution (pH 7.4) at 37℃ will release free 5FU. The dendrimer seems to be a promising carrier for the controlled release of anti-tumor drugs.
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Received: 06 May 2008
Published: 01 January 1900
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