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Inducing of insulin producing like cell with bone marrow-derived mesenchymal stem cell |
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Abstract Diabetes mellitus is one of the heading causes of morbidity and mortality in many countries .It caused by an absolute insulin deficiency due to the destruction of insulin secreting pancreatic cells or by a relative insulin deficiency due to decreased insulin sensitivity, characterized with choronic hyperglycemia. Islet transplantation has been shown to restore normoglycemia ,but a limited supply and graft immune rejection prevents this therapy. Mesenchymal stem cells have the potency of differentiation into islet cells, it may act as a new source of islet transplantation in diabetes mellitus treatment.
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Received: 20 December 2005
Published: 15 June 2006
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