中国生物工程杂志

Chemokine receptor 5 (CCR5 ),as a member of the G protein-coupled receptor （GPCR）superfamily，is a membrane protein on cell surface and one of the major of coreceptors for HIV-1infection.CCR5 has became a molecular target for the novel drugs against HIV-1,and Antagonists for CCR5 could be grouped as following, chemokine derivatives,small molecule non-peptide compounds,molecular antibodies and peptides. These compounds with high anti-viral activity and affinity are at different stages, and some have been under clinical studies.This review is about the development research in the different kind of CCR5 antagonists.