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| Natural Anti-infectious Molecule: Bactericidal/ permeability- increasing Protein |
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Abstract Endotoxins are lipopolysaccharides (LPS), major component out wall in Gram- negative bacteria. And they often are considered as "prime criminals" of triggering systemic inflaming reaction such as sepsis or bacteremia and so on. It was found in recent years that bactericidal/permeability-increasing protein, a 55kD member of lipid-related protein family, was a kind of natural molecule of anti-infection and it has special endotoxin-neutralising activity and antibacterial activity. Comprehensive Phase Ⅱ/Ⅲ clinical trials demonstrated the feasibility and safety of recombinant BPI. Above all attract pharmaceutical corporations to try to apply it to therapy.
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Received: 04 January 2006
Published: 25 July 2006
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