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| Progress in the Study of Microbial tRNA and Genetic Codon System Related Applications |
LIAO Dan-ni,ZHANG Zhao-yang,JIN Jin,LI Xia,JIA Bin( ) |
| Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University, Tianjin 300072, China |
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Abstract The tRNA are important molecules of the translation process in the central dogma of life. The type and abundance of tRNA have a huge impact on the synthesis of proteins. In recent years, many inspirations have been obtained through the analysis of the structure and function of microbial tRNA and the process of tRNA modification. Moreover, the study of genetic codon expansion has realized the incorporation of unnatural amino acids into specific positions to obtain new functional proteins. At the same time, the codon recoding work carried out through chemical synthesis of microbial genomes will release more codons and tRNAs for more genetic codon expansion research. This work reviewed the latest application research progress of microbial tRNA and codon system in synthetic biology, and discussed the future development trend.
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Received: 04 January 2021
Published: 30 April 2021
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Corresponding Authors:
Bin JIA
E-mail: bin.jia@tju.edu.cn
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