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| Research Progress of CircularRNAs |
| XU Yan1, ZHAO Xue1, DU Jing-jing1, YANG Qiong2, YANG Da-hong3, PU Hong-zhou4, ZHANG Shun-hua1, ZHU Li1 |
| Sichuan Agricultural University, Chengdu 611130, China |
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Abstract Circular RNA (circRNA) is a novel type of endogenous noncoding RNA. Unlike linear RNAs that are terminated with 5'caps and 3'tails, circRNAs form covalently closed loop structures with neither 5'~3'polarities nor polyadenylated tails, by reverse splicing. circRNAs were typically considered to be by-products of aberrant RNA splicing due to their low levels of expression. However, with the development of RNA deep sequencing technology and bioinformatics, more circRNAs have been identified. circRNA is endogenous, abundant, conserved and stable in mammalian cells, and often show specific expression or developmental model in tissue, and there are differences in subcellular localization. Many studies have shown that circRNAs play an important role in the regulation of animal growth and development, which is also closely associated with the occurrence and development of diseases. Here, the discovery, formation, characteristics, mechanism, research methods and current research progress of circRNA were reviewed, it may contribute to further studies.
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Received: 06 June 2017
Published: 25 October 2017
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