Optimization of Induced Pluripotent Stem Cell Technology and Its Application Prospect

doi:10.13523/j.cb.20160612

China Biotechnology

2016, Vol. 36

Issue (6): 87-91 DOI: 10.13523/j.cb.20160612

Optimization of Induced Pluripotent Stem Cell Technology and Its Application Prospect

XIA Meng¹, TIAN Xiao-hong², BAI Shu-ling², HOU Wei-jian²

1. The 1st Department of Clinical Medicine, China Medical University, Shenyang 110122, China;
2. Department of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang 110122, China

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Abstract

Induced pluripotent stem cells (iPSCs) are a type of cells similar to embryonic stem cells (ESCs) which have the characters of self-renewal and pluripotency.They can be obtained through the induced reprogramming of differentiated somatic cells.iPSC has broad application prospects in the establishment of disease models in vitro,regenerative medicine,embryology etc. The controversies and obstacles that challenge the field are its tumorigenicity,low transformation efficiency and the low degree of fitting of the disease models. The majorizations of method on reprogramming were summarized, and the ways to increase transformation efficiency and reduce tumorigenicity were emphasized.The application prospects of iPS in clinical therapy and scientific research in the future were explored

Key words： Tumorigenicity Induced pluripotent stem cells Transformation efficiency Reprogramming

Received: 21 March 2016 Published: 25 June 2016

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XIA Meng, TIAN Xiao-hong, BAI Shu-ling, HOU Wei-jian. Optimization of Induced Pluripotent Stem Cell Technology and Its Application Prospect. China Biotechnology, 2016, 36(6): 87-91.

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https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20160612 OR https://manu60.magtech.com.cn/biotech/Y2016/V36/I6/87

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