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China Biotechnology
China Biotechnology  2015, Vol. 35 Issue (10): 115-121    DOI: 10.13523/j.cb.20151017
The Research Progress of Marine Functional Molecules Phloroglucinol
WANG Rong-hua2, SUN Xiu-juan1, LI Qian1, YAN Zhen-xin1, Peter Proksch1
1. Shouguang Fukang Pharmaceutical Co.Ltd.R&D, Shouguang 262700, China;
2. Weihai Municipal Maternal and Child Health Hospita Pharmacy Departmentl, Weihai 264200, China
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The marine pharmacology research is getting stronger and stronger. Recent research has focused on the study of specific activity of marine natural products, and applied to new drugs for human. Phloroglucinol is a kind of important pharmaceutical intermediates. It is widely distributed in marine alga,especially in Phaeophyta. As a non-atropine non-papaverine class smooth muscle spasmolysis medicine,phloroglucinol primarily treat a variety of acute spasmodic pain. It is the first choosed drug in the treatment of gastrointestinal, genitourinary tract spasms and contractions during pregnancy, for its fast-acting, less side effects. Now, phloroglucinol is mainly produced by chemical synthesis. But the chemical method has many disadvantages, so biological synthesis become a potential method and research hot spot to produce phloroglucinol. The mechanisms and the methods of phloroglucinol biosynthesis are reviewed. In addition, it also sums up the main applications of phloroglucinol.

Key wordsPhloroglucinol      Biosynthesis      Chemical synthesis      Application     
Received: 02 April 2015      Published: 25 October 2015
ZTFLH:  Q819  
Cite this article:

WANG Rong-hua, SUN Xiu-juan, LI Qian, YAN Zhen-xin, Peter Proksch. The Research Progress of Marine Functional Molecules Phloroglucinol. China Biotechnology, 2015, 35(10): 115-121.

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