Please wait a minute...

中国生物工程杂志

China Biotechnology
China Biotechnology  2015, Vol. 35 Issue (10): 78-85    DOI: 10.13523/j.cb.20151012
    
Study of Courtship Behavior Molecular Regulatory Mechanism in Drosophila
HE Shi-bao1,2, LI Guan-nan1,2, GUO Dong-dong1,2, TANG Wen-chao1,2, LONG Yao-hang1,2, ZHU Yong1,2
1. College of Biotechnology, Southwest University, Chongqing 400715, China;
2. State Key Laboratory of Silkworm Genome Biology, Chongqing 400715, China
Download: HTML   PDF(1047KB) HTML
Export: BibTeX | EndNote (RIS)      

Abstract  

Courtship behavior regulated by multiple gene in Drosophila, such as fruitless (fru), dissatisfaction (dsf) and retained (retn), etc. Using of these products that were produce specific products by different splicing pattern to control the courtship behavior of male and female in Drosophila, whose splicing pattern is necessary for courtship behavior and sex determination in both male and female. The molecular regulation of these genes that regulate courtship behavior in Drosophila was reviewed and summarized for providing theoretical basis to further study the courtship behavior and sex determination.



Key wordsDrosophila      Courtship behavior      Sex determination      Splicing pattern     
Received: 02 June 2015      Published: 25 October 2015
ZTFLH:  Q965  
Cite this article:

HE Shi-bao, LI Guan-nan, GUO Dong-dong, TANG Wen-chao, LONG Yao-hang, ZHU Yong. Study of Courtship Behavior Molecular Regulatory Mechanism in Drosophila. China Biotechnology, 2015, 35(10): 78-85.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20151012     OR     https://manu60.magtech.com.cn/biotech/Y2015/V35/I10/78

[1] 刘若楠, 颜忠诚. 昆虫求偶行为方式及生物学意义. 生物学通报, 2009, 43(9): 6-8. Liu R N, Yan Z C. Courtship behavior style and biological significance in insects. Bulletin of Biology, 2009, 43(9): 6-8.
[2] Yamamoto D, Jallon J M, Komatsu A. Genetic dissection of sexual behavior in Drosophila melanogaster. Annual Review of Entomology, 1997, 42(1): 551-585.
[3] Spieth H T. Courtship behavior in Drosophila. Annual Review of Entomology, 1974, 19(1): 385-405.
[4] Rideout E J, Dornan A J, Neville M C, et al. Control of sexual differentiation and behavior by the doublesex gene in Drosophila melanogaster. Nature Neuroscience, 2010, 13(4):458-466.
[5] venken K J, Simpson J H, Bellen H J. Genetic manipulation of genes and cells in the nervous system of the fruit fly. Neuron, 2011,72(2):202-230.
[6] Pan Y, Robinett C C, Baker B S. Turning males on: activation of male courtship behavior in Drosophila melanogaster. PLos One, 2011, 6:e21144-e21158.
[7] Pan Y, Messner G W, Baker B S. Joint control of Drosophila male courtship behavior by motion cues and activation of male-specific P1 neurons. Proc Natl Acad Sci USA, 2012, 109(25):10065-10070.
[8] von Philipsborn A C, Liu T, Yu J Y, et al. Neuronal control of Drosophila courtship song. Neuron, 2011, 69(3):509-522.
[9] Rezával C, Pavlou H J, Dornan A J, et al. Neural circuitry underlying Drosophila female postmating behavioral responses. Current Biology, 2012, 22(13): 1155-1165.
[10] Gill K S. A mutation causing abnormal courtship and mating behavior in males of Drosophila melanogaster. American Zoologist, 1963, 3: 507.
[11] Hall J C. Courtship among males due to a male-sterile mutation in Drosophila melanogaster. Behavior Genetics, 1978, 8(2): 125-141.
[12] Ito H, Fujitani K, Usui K, et al. Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain. Proc Natl Acad Sci USA, 1996, 93(18): 9687-9692.
[13] Ryner L C, Goodwin S F, Castrillon D H, et al. Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell, 1996, 87(6): 1079-1089.
[14] Zollman S, Godt D, Privé G G, et al. The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc Natl Acad Sci USA, 1994, 91(22): 10717-10721.
[15] Clynen E, Bellés X, Piulachs M D. Conservation of fruitless role as master regulator of male courtship behaviour from cockroaches to flies. Development Genes and Evolution, 2011, 221(1): 43-48.
[16] Takayanagi S, Toba G, Lukacsovich T, et al. A fruitless upstream region that defines the species specificity in the male-specific muscle patterning in Drosophila. Journal of Neurogenetics, 2014, 29(1): 23-29.
[17] Bjorum S M, Simonette R A, Alanis R, et al. The Drosophila BTB domain protein Jim Lovell has roles in multiple larval and adult behaviors. Plos One, 2013, 8(4): e61270-e61286.
[18] Dalton J E, Fear J M, Knott S, et al. Male-specific Fruitless isoforms have different regulatory roles conferred by distinct zinc finger DNA binding domains. BMC Genomics, 2013, 14(1): 659-673.
[19] Nojima T, Neville M C, Goodwin S F. Fruitless isoforms and target genes specify the sexually dimorphic nervous system underlying Drosophila reproductive behavior. Fly, 2014, 8(2): 95-100.
[20] Sadler A J, Rossello F J, Yu L, et al. BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci USA, 2015, 112(5): 1535-1540.
[21] Lee G, Foss M, Goodwin S F, et al. Spatial, temporal, and sexually dimorphic expression patterns of the fruitless gene in the Drosophila central nervous system. Journal of Neurobiology, 2000, 43(4): 404-426.
[22] Demir E, Dickson B J. Fruitless splicing specifies male courtship behavior in Drosophila. Cell, 2005, 121(5): 785-794.
[23] Salvemini M, Polito C, Saccone G. Fruitless alternative splicing and sex behaviour in insects: an ancient and unforgettable love story? Journal of Genetics, 2010, 89(3): 287-299.
[24] Parker D J, Gardiner A, Neville M C, et al. The evolution of novelty in conserved genes; evidence of positive selection in the Drosophila fruitless gene is localised to alternatively spliced exons. Heredity, 2014, 112(3): 300-306.
[25] Vrontou E, Nilsen S P, Demir E, et al. Fruitless regulates aggression and dominance in Drosophila. Nature Neuroscience, 2006, 9(12): 1469-1471.
[26] von Philipsborn A C, Jörchel S, Tirian L, et al. Cellular and behavioral functions of fruitless isoforms in Drosophila courtship. Current Biology, 2014, 24(3): 242-251.
[27] Boerjan B, Tobback J, Loof A, et al. Fruitless RNAi knockdown in males interferes with copulation success in Schistocerca gregaria. Insect Biochemistry and Molecular Biology, 2011, 41(5): 340-347.
[28] Finley K D, Taylor B J, Milstein M, et al. Dissatisfaction, a gene involved in sex-specific behavior and neural development of Drosophila melanogaster. Proc Natl Acad Sci USA, 1997, 94(3): 913-918.
[29] Finley K D, Edeen P T, Foss M, et al. Dissatisfaction encodes a tailless-like nuclear receptor expressed in a subset of CNS neurons controlling Drosophila sexual behavior. Neuron, 1998, 21(6): 1363-1374.
[30] Pitman J L, Tsai C C, Edeen P T, et al. DSF nuclear receptor acts as a repressor in culture and in vivo. Developmental Biology, 2002, 245(2): 315-328.
[31] Yamamoto D, Nakano Y. Sexual behavior mutants revisited: molecular and cellular basis of Drosophila mating. Cellular and Molecular Life Sciences, 1999, 56(7-8): 634-646.
[32] Shandala T, Kortschak R D, Saint R. The Drosophila retained/dead ringer gene and ARID gene family function during development. International Journal of Developmental Biology, 2002, 46(4): 423-430.
[33] Shandala T, Takizawa K, Saint R. The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS. Development, 2003, 130(8): 1505-1513.
[34] Datta S R, Vasconcelos M L, Ruta V, et al. The Drosophila pheromone cVA activates a sexually dimorphic neural circuit. Nature, 2008, 452(7186):473-477.
[35] Goto J, Mikawa Y, Koganezawa M, et al. Sexually dimorphic shaping of interneuron dendrites involves the hunchback transcription factor. Journal of Neuroscience, 2011, 31(14): 5454-5459.
[36] Kimura K. Role of cell death in the formation of sexual dimorphism in the Drosophila central nervous system. Development Growth & Differentiation, 2011, 53(2), 236-244.
[37] Ito H, Sato K, Koganezawa M, et al. Fruitless recruits two antagonistic chromatin factors to establish single-neuron sexual dimorphism. Cell, 2012, 149(6): 1327-1338.
[38] Vernes S C. Genome wide identification of Fruitless targets suggests a role in upregulating genes important for neural circuit formation. Scientific Reports, 2014, 4:4412-4422.
[39] Baker B S, Taylor B J, Hall J C. Are complex behaviors specified by dedicated regulatory genes? Reasoning from Drosophila. Cell, 2001, 105(1): 13-24.
[40] Stockinger P, Kvitsiani D, Rotkopf S, et al. Neural circuitry that governs Drosophila male courtship behavior. Cell, 2005, 121(5): 795-807.
[41] Garcia-Bellido A. Genetic Control of Wing Disc Development in Drosophila. Amsterdam:Elsevier, 1975, 0(29): 161-182.
[42] Shirangi T R, Taylor B J, McKeown M. A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Nature Genetics, 2006, 38(12): 1435-1439.
[43] Sato K, Yamamoto D. An epigenetic switch of the brain sex as a basis of gendered behavior in Drosophila. Advances in Genetics, 2014, 86: 45-63.
[44] Usui-Aoki K, Ito H, Ui-Tei K, et al. Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression. Nature Cell Biology, 2000, 2(8): 500-506.
[45] Pan Y, Baker B S. Genetic identification and separation of innate and experience-dependent courtship behaviors in Drosophila. Cell, 2014, 156(1): 236-248.
[46] Tran D H, Meissner G W, French R L, et al. A small subset of fruitless subesophageal neurons modulate early courtship in Drosophila. Plos One, 2014, 9(4): e95472-e95481.
[47] Devineni A V, Heberlein U. Acute ethanol responses in Drosophila are sexually dimorphic. Proc Natl Acad Sci USA, 2012, 109(51): 21087-21092.
[48] Billeter J C, Goodwin S F. Characterization of Drosophila fruitless-gal4 transgenes reveals expression in male-specific fruitless neurons and innervation of male reproductive structures. Journal of Comparative Neurology, 2004, 475(2): 270-287.
[49] Latham K L, Liu Y S, Taylor B J. A small cohort of FRUM and Engrailed-expressing neurons mediate successful copulation in Drosophila melanogaster. BMC Neuroscience, 2013, 14(1): 57-72.
[50] Lim M M, Wang Z, Olazábal D E, et al. Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nature, 2004, 429(6993): 754-757.
[51] Alekseyenko O V, Chan Y B, Fernandez M L, et al. Single serotonergic neurons that modulate aggression in Drosophila. Current Biology, 2014, 24(22): 2700-2707.
[52] Lee G, Hall J C. Abnormalities of male-specific FRU protein and serotonin expression in the CNS of fruitless mutants in Drosophila. Journal of Neuroscience, 2001, 21(2): 513-526.
[53] Yamamoto D, Usui-Aoki K, Shima S. Male-specific expression of the Fruitless protein is not common to all Drosophila species. Genetica, 2004, 120(1-3): 267-272.
[54] Shirangi T R, McKeown M. Sex in flies: What ‘body-mind’ dichotomy? Developmental Biology, 2007, 306(1): 10-19.
[55] O'Kane C J, Asztalos Z. Sexual behaviour: courting dissatisfaction. Current Biology, 1999, 9(8):289-292.
[56] Yamamoto D, Fujitani K, Usui K, et al. From behavior to development: genes for sexual behavior define the neuronal sexual switch in Drosophila. Mechanisms of Development, 1998, 73(2): 135-146.
[57] Ditch L M, Shirangi T, Pitman J L, et al. Drosophila retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors. Development, 2005, 132(1): 155-164.
[58] Gregory S L, Kortschak R D, Kalionis B, et al. Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins. Molecular and Cellular Biology, 1996, 16(3): 792-799.
[59] Valentine S A, Chen G, Shandala T, et al. Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer. Molecular and Cellular Biology, 1998, 18(11): 6584-6594.
[60] Shandala T, Kortschak R D, Gregory S, et al. The Drosophila dead ringer gene is required for early embryonic patterning through regulation of argos and buttonhead expression. Development, 1999, 126(19): 4341-4349.
[61] Hall J C. The mating of a fly. Science, 1994, 264(5166): 1702-1714.
[62] Cline T W, Meyer B J. Vive la difference: males vs females in flies vs worms. Annual Review of Genetics, 1996, 30(1): 637-702.
[63] Ferveur J F, Störtkuhl K F, Stocker R F, et al. Genetic feminization of brain structures and changed sexual orientation in male Drosophila. Science, 1995, 267(5199): 902-905.
[64] Arthur B I, Jallon J M, Caflisch B, et al. Sexual behaviour in Drosophila is irreversibly programmed during a critical period. Current Biology, 1998, 8(21): 1187-1190.
[65] Kimura K, Ote M, Tazawa T, et al. Fruitless specifies sexually dimorphic neural circuitry in the Drosophila brain. Nature, 2005, 438(7065):229-233.
[66] Kimura K, Hachiya T, Koganezawa M, et al. Fruitless and doublesex coordinate to generate male-specific neurons that can initiate courtship. Neuron, 2008, 59(5):759-769.
[67] Rezával C, Nojima T, Neville M C, et al. Sexually dimorphic octopaminergic neurons modulate female postmating behaviors in Drosophila. Current Biology, 2014, 24(7): 725-730.
[68] Sosnowski B A, Belote J M, McKeown M. Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage. Cell, 1989, 58(3): 449-459.
[69] Fagegaltier D, König A, Gordon A, et al. A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity. Genetics, 2014, 198(2): 647-668.
[70] Dauwalder B. The roles of fruitless and doublesex in the control of male courtship. International review of neurobiology, 2011, 99: 87-105.
[71] Salvemini M, D'Amato R, Petrella V, et al. The orthologue of the fruitfly sex behaviour gene fruitless in the mosquito Aedes aegypti: evolution of genomic organisation and alternative splicing. Plos One, 2013, 8(2): e48554-e48570.
[72] Chatterjee S S, Uppendahl L D, Chowdhury M A, et al. The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. Development, 2011, 138(6), 1099-1109.
[73] Luo S D, Shi G W, Baker B S. Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. Development, 2011, 138(13): 2761-2771.
[74] Zhou C, Pan Y, Robinett C C, et al. Central brain neurons expressing doublesex regulate female receptivity in Drosophila. Neuron, 2014, 83(1): 149-163.

[1] LIAO Bing, TUN Ning, HAN Feng-Dong, LIN Xiu-Kun. Cloning and bioinformatics analysis of Fgf9, a novel gene related to sex determination in cow[J]. China Biotechnology, 2009, 29(08): 45-50.