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中国生物工程杂志

China Biotechnology
China Biotechnology  2015, Vol. 35 Issue (10): 13-19    DOI: 10.13523/j.cb.20151002
    
The Function and Mechanism of MicroRNA-124 in Human Cervical Cancer
XIN Jing, XU Yin-sheng, ZHANG Fang, SHENG Wang
College of life Science and Bio-engineering, Beijing University of Technology, Beijing 100124, China
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Abstract  

Cervical cancer is the second most common malignant tumor in women around the world. The expression of miR-124 is significantly down-regulated in cervical cancer. The results showed that exogenous expression of miR-124 could remarkably suppress the proliferation and migration of cervical cancer cells. Luciferase analysis showed that CUB domain containing protein 1 gene (Cdcp1) is a direct down-stream target of miR-124 and restoration of CDCP1 counteracted the tumor suppressive effects of miR-124. The results have a great potential for not only the understanding of the relationship between miRNA and cervical cancer, but also microRNA-based anti-cervical cancer therapy.



Key wordsCDCP1      Cervical cancer      microRNA-124     
Received: 28 April 2015      Published: 25 October 2015
ZTFLH:  Q74  
Cite this article:

XIN Jing, XU Yin-sheng, ZHANG Fang, SHENG Wang. The Function and Mechanism of MicroRNA-124 in Human Cervical Cancer. China Biotechnology, 2015, 35(10): 13-19.

URL:

https://manu60.magtech.com.cn/biotech/10.13523/j.cb.20151002     OR     https://manu60.magtech.com.cn/biotech/Y2015/V35/I10/13

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